Lipid-coated ZnO nanoparticles synthesis, characterization and cytotoxicity studies in cancer cell

Cao Dingding; Shu Xugang; Zhu Dandan; Liang Shengli; Hasan Murtaza; Gong Sheng

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자료유형: 학술저널

저자정보: Cao Dingding (Zhongkai University of Agriculture and Engineering) Shu Xugang (Zhongkai University of Agriculture and Engineering) Zhu Dandan (Zhongkai University of Agriculture and Engineering) Liang Shengli (Zhongkai University of Agriculture and Engineering) Hasan Murtaza (Zhongkai University of Agriculture and Engineering) Gong Sheng (Zhongkai University of Agriculture and Engineering)

저널정보: 나노기술연구협의회 Nano Convergence Nano Convergence Vol.7 No.14

발행연도: 2020.1

수록면: 1 - 18 (18page)

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ZnO nanoparticles are widely used in biological, chemical, and medical fields, but their toxicity impedes their wide application. In this study, pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm) and lipid-coated ZnO NPs (~ 13 nm; ~ 22 nm; ~ 52 nm) with different morphologies were prepared by chemical method and characterized by TEM, XRD, HRTEM, FTIR, and DLS. Our results showed that the lipid-coated ZnO NPs (~ 13 nm; ~ 22 nm; ~ 52 nm) groups improved the colloidal stability, prevented the aggregation and dissolution of nanocrystal particles in the solution, inhibited the dissolution of ZnO NPs into Zn 2+ cations, and reduced cytotoxicity more efficiently than the pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm). Compared to the lipid-coated ZnO NPs, pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm) could dose-dependently destroy the cells at low concentrations. At the same concentration, ZnO NPs (~ 7 nm) exhibited the highest cytotoxicity. These results could provide a basis for the toxicological study of the nanoparticles and direct future investigations for preventing strong aggregation, reducing the toxic effects of lipid-bilayer and promoting the uptake of nanoparticles by HeLa cells efficiently.

#Zinc oxide #Nanocrystals synthesis #Lipid-coated ZnO #Cytotoxicity

참고문헌 (71)

참고문헌 신청

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