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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 46 - 51 (6page)
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초록· 키워드
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Background: Brainstem encephalitis is a rare, severe, and potentially life-threatening inflammation of the central nervous system, exhibiting various treatment responses and outcomes owing to multiple etiologies. Case Report: We describe the favorable outcome of salvage immunotherapy using a combination of infliximab and methotrexate in a 62-year-old woman with refractory brainstem encephalitis. The patient was initially presumed to be at a subacute stage of medullary infarction but showed progressively worsening conditions involving cervical myelopathy, despite having completed the schedule of subsequent immunotherapy with intravenous methylprednisolone, immunoglobulin, and rituximab. After completion of four sessions of weekly rituximab injection, she was treated with 5 mg/kg of infliximab, scheduled at 0, 2, and 6 weeks, along with methotrexate (weekly 12.5 mg). After completion of infliximab injection and maintenance with methotrexate treatment, she showed an improving course of quadriplegia. Conclusion: This case report provides evidence for the potential efficacy of infliximab with methotrexate in cases of refractory brainstem encephalitis.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Tan IL / 2013 / Brainstem encephalitis : etiologies, treatment, and predictors of outcome / J Neurol 260:2312~2319
Bin Abdulqader SA / 2018 / Brainstem encephalitis : a diagnostic dilemma / Neurosciences(Riyadh) 23:152~157
Law LY / 2019 / The spectrum of immune-mediated and inflammatory lesions of the brainstem : clues to diagnosis / Neurology 93:390~405
Overell JR / 2007 / Treatment for Fisher syndrome, Bickerstaff's brainstem encephalitis and related disorders / Cochrane Database Syst Rev (1):CD004761
Hermetter C / 2018 / Systematic review : syndromes, early diagnosis, and treatment in autoimmune encephalitis / Front Neurol 9:706
Bin Abdulqader SA / 2018 / Brainstem encephalitis : a diagnostic dilemma / Neurosciences(Riyadh) 23:152~157
Law LY / 2019 / The spectrum of immune-mediated and inflammatory lesions of the brainstem : clues to diagnosis / Neurology 93:390~405
Overell JR / 2007 / Treatment for Fisher syndrome, Bickerstaff's brainstem encephalitis and related disorders / Cochrane Database Syst Rev (1):CD004761
Hermetter C / 2018 / Systematic review : syndromes, early diagnosis, and treatment in autoimmune encephalitis / Front Neurol 9:706
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