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논문 기본 정보

자료유형
학술저널
저자정보
Emre Kumral (Department of Neurology Ege University Medical School Hospital Izmir Turkey) Fatma Ece Bayam (Department of Neurology Ege University Medical School Hospital Izmir Turkey) Bedriye Köken (Department of Neurology Ege University Medical School Hospital Izmir Turkey) Can Emre Erdoğan (Department of Neurology Ege University Medical School Hospital Izmir Turkey)
저널정보
대한신경집중치료학회 Journal of Neurocritical Care Journal of Neurocritical Care Vol.12 No.1
발행연도
2019.1
수록면
37 - 45 (9page)

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Background: Patients with persistent vegetative state (PVS) show no evidence of awareness of self or their environment, and those with minimally conscious state (MCS) have severely impaired consciousness with minimal but definite behavioral evidence of self or environmental awareness after stroke. Neuroimaging and clinical characteristics separating these two close consciousness states after stroke were insufficiently studied. Methods: We conducted a hospital-based cohort study of all patients with stroke (2011 to 2017) who underwent 3T magnetic resonance imaging and consciousness assessment after 3 months of inclusion. Univariate and multivariate regression analyses were used to estimate the relative risk of neuroimaging markers for differentiation of PVS and MCS. Results: Of 3,600 eligible subjects, 323 patients (0.09%) had PVS and 93 (0.02%) had MCS (mean age, 62.25±13.4 years). Higher stroke volume was strongly associated with PVS compared to MCS (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98 to 1.00; P=0.001). On univariate analysis, cingulate gyrus (OR, 2.7; 95% CI, 1.62 to 4.36; P=0.001) and corpus callosum (OR, 2.1; 95% CI, 1.28 to 3.44; P=0.003) involvement was significantly associated with PVS. However, on multivariate analysis, only cingulate gyrus involvement was independently associated with PVS (OR, 2.2; 95% CI, 1.33 to 3.72; P=0.002). Conclusion: Our results indicate that PVS and MCS are different consciousness states according to clinical and neuroimaging findings. To predict outcome, cognitive performance of these patients should be well questioned after stroke.

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