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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 97 - 107 (11page)
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초록· 키워드
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The pathogenesis of hepatocellular carcinoma (HCC) is a complex process. During the last decade, advances in genomic technologies enabled delineation of the genomic landscape of HCC, resulting in the identification of the common underlying molecular alterations. The tumor microenvironment, regulated by inflammatory cells, including cancer cells, stromal tissues, and the surrounding extracellular matrix, has been extensively studied using molecular data. The integration of molecular, immunological, histopathological, and clinical findings has provided clues to uncover predictive biomarkers to enhance responses to novel therapies. Herein, we provide an overview of the current HCC genomic landscape, previously identified gene signatures that are used routinely to predict prognosis, and an immune-specific class of HCC. Since biomarker-driven treatment is still an unmet need in HCC management, translation of these discoveries into clinical practice will lead to personalized therapies and improve patient care, especially in the era of targeted and immunotherapies.
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참고문헌 (65)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Heimbach JK / 2018 / AASLD guidelines for the treatment of hepatocellular carcinoma / Hepatology 67:358~380
Korean Association for the Study of the Liver (KASL) / 2019 / KASL clinical practice guidelines for management of chronic hepatitis B / Clinical and Molecular Hepatology 25(2):93~159
Cancer Genome Atlas Research Network / 2017 / Comprehensive and integrative genomic characterization of hepatocellular carcinoma / Cell 169:1327~1341.e23
Heptromic / Genomic predictors and oncogenic drivers in hepatocellular carcinoma / IDIBAPSInstitut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Heimbach JK / 2018 / AASLD guidelines for the treatment of hepatocellular carcinoma / Hepatology 67:358~380
Korean Association for the Study of the Liver (KASL) / 2019 / KASL clinical practice guidelines for management of chronic hepatitis B / Clinical and Molecular Hepatology 25(2):93~159
Cancer Genome Atlas Research Network / 2017 / Comprehensive and integrative genomic characterization of hepatocellular carcinoma / Cell 169:1327~1341.e23
Heptromic / Genomic predictors and oncogenic drivers in hepatocellular carcinoma / IDIBAPSInstitut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
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