지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
More than 80% of patients with pancreatic ductal adenocarcinoma (PDA) present with symptomatic, surgically unresectable disease. If a “stage shift” from the current 20% resectable proportion to greater by early detection can be achieved, it will unequivocally lead to improved survival in this otherwise dismal disease. Although the goal of early detection of PDA is laudable, the relatively low prevalence PDA renders general population screening infeasible. To avoid the perils of overdiagnosis and to focus early detection efforts on individuals deemed to be at higher-than-average risk, we need to define those subsets of individuals, such as familial kindred and patients with precursor cystic lesions, chronic pancreatitis, and new-onset diabetes. The next step is to determine when and how often to conduct surveillance in the atrisk individuals and the modalities (biomarkers and imaging) that will be used in the surveillance and diagnostic settings, respectively. Nonetheless, vast challenges still remain in terms of validated blood-based biomarkers, imaging modality, and when and how often the surveillance.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Wood LD / 2019 / Genetics of familial and sporadic pancreatic cancer / Gastroenterology 156:2041~2055
Vasen H / 2016 / Benefit of surveillance for pancreatic cancer in high-risk individuals : outcome of long-term prospective follow-up studies from three European Expert Centers / J Clin Oncol 34:2010~2019
Canto MI / 2018 / Risk of neoplastic pro gression in individuals at high risk for pancreatic cancer undergoing long-term surveillance / Gastroenterology 155:740~751.e742
Raimondi S / 2010 / Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection / Best Pract Res Clin Gastroenterol 24:349~358
Kirkegård J / 2017 / Chronic pancreatitis and pancreatic cancer risk : a systematic review and meta-analysis / Am J Gastroenterol 112:1366~1372
Vasen H / 2016 / Benefit of surveillance for pancreatic cancer in high-risk individuals : outcome of long-term prospective follow-up studies from three European Expert Centers / J Clin Oncol 34:2010~2019
Canto MI / 2018 / Risk of neoplastic pro gression in individuals at high risk for pancreatic cancer undergoing long-term surveillance / Gastroenterology 155:740~751.e742
Raimondi S / 2010 / Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection / Best Pract Res Clin Gastroenterol 24:349~358
Kirkegård J / 2017 / Chronic pancreatitis and pancreatic cancer risk : a systematic review and meta-analysis / Am J Gastroenterol 112:1366~1372
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