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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 149 - 156 (8page)
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초록· 키워드
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Background and Objectives: The gap prepulse inhibition of the acoustic startle response has been used to screen tinnitus in an animal model. Here, we examined changes in the auditory late response under various conditions of gap prepulse inhibition.Subjects and Methods: We recruited 19 healthy adults (5 males, 14 females) and their auditory late responses were recorded after various stimuli with or without gap prepulsing. The N1 and P2 responses were selected for analysis. The gap prepulse inhibition was estimated to determine the optimal auditory late response in the gap prepulse paradigm.Results: We found that the gap per se generated a response that was very similar to the response elicited by sound stimuli. This critically affected the gap associated with the maximal inhibition of the stimulus response. Among the various gap-stimulus intervals (GSIs) between the gap and principal stimulus, the GSI of 150 ms maximally inhibited the response. However, after zero padding was used to minimize artifacts after a P2 response to a gap stimulus, the differences among the GSIs disappeared.Conclusions: Overall, the data suggest that both the prepulse inhibition and the gap per se should be considered when using the gap prepulse paradigm to assess tinnitus in humans.
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참고문헌 (29)
참고문헌 신청
Norena A / 1999 / Towards an objectification by classification of tinnitus / Clin Neurophysiol 110:666~675
Lee CY / 2007 / Auditory cortical evoked potentials in tinnitus patients with normal audiological presentation / J Formos Med Assoc 106:979~985
Graham FK / 1975 / Presidential Address, 1974. The more or less startling effects of weak prestimulation / Psychophysiology 12:238~248
Swerdlow NR / 2000 / Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon / Behav Pharmacol 11:185~204
Kedzior KK / 2006 / Chronic cannabis use is associated with attention-modulated reduction in prepulse inhibition of the startle reflex in healthy humans / J Psychopharmacol 20:471~484
Lee CY / 2007 / Auditory cortical evoked potentials in tinnitus patients with normal audiological presentation / J Formos Med Assoc 106:979~985
Graham FK / 1975 / Presidential Address, 1974. The more or less startling effects of weak prestimulation / Psychophysiology 12:238~248
Swerdlow NR / 2000 / Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon / Behav Pharmacol 11:185~204
Kedzior KK / 2006 / Chronic cannabis use is associated with attention-modulated reduction in prepulse inhibition of the startle reflex in healthy humans / J Psychopharmacol 20:471~484
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