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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 671 - 683 (13page)
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Background: Osteomyelitis resulting from bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to multiple drugs, brings further clinical challenges. There is currently no model of osteomyelitis induced by MRSA using rats with calvaria defects. So, We induced osteomyelitis in rat models with the calvaria bone defect. Methods: The rats were randomly divided into six groups according to inoculation dose levels, which ranged from 6 × 100 to 6 × 105 CFU/5 µl. Bone tissues were retrieved from all rats used in the study and assessed using histology, microbiology, and radiobiology 4 weeks after surgery to evaluate the relationship between inoculation dose and infectivity. Results: In Histological results, high levels of inflammatory responses, bone necrosis, and bacteria were observed in treatment groups G3 to G5. In IHC staining, high levels of cox-2 expression were observed in treatment groups G3. Microbiological observations also indicated that significantly higher numbers of CFUs were found in G3 to G5. In radiography results, the bone mineral density in G3 to G5 was significantly higher than in the control group, G1, and G2. Our results indicate that an inoculating dose of 6 × 103 CFU/5 μl is sufficient to induce the development of osteomyelitis in rat models. Conclusion: This study suggests that the minimum dose (6 × 103 CFU/5 µl) can induce osteomyelitis in calvaria rat model. This can offer information and ability of more accurately modeling osteomyelitis and simulating the challenge of osteomyelitis treat.
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참고문헌 (40)
참고문헌 신청
Lio P / 2012 / Modelling osteomyelitis / BMC Bioinformatics 13:S12
Montanaro L / 2007 / Advancements in molecular epidemiology of implant infections and future perspectives / Biomaterials 28:5155~5168
Tan H / 2012 / The use of antimicrobial-impregnated PMMA to manage periprosthetic infections : controversial issues and the latest developments / Int J Artif Organs 35:832~839
Cherng A / 1997 / Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement / J Biomed Mater Res 35:273~277
Marriott I / 2013 / Apoptosis-associated uncoupling of bone formation and resorption in osteomyelitis / Front Cell Infect Microbiol 3:101
Montanaro L / 2007 / Advancements in molecular epidemiology of implant infections and future perspectives / Biomaterials 28:5155~5168
Tan H / 2012 / The use of antimicrobial-impregnated PMMA to manage periprosthetic infections : controversial issues and the latest developments / Int J Artif Organs 35:832~839
Cherng A / 1997 / Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement / J Biomed Mater Res 35:273~277
Marriott I / 2013 / Apoptosis-associated uncoupling of bone formation and resorption in osteomyelitis / Front Cell Infect Microbiol 3:101
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