지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 283 - 293 (11page)
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초록· 키워드
오류제보하기
Osteomyelitis, an infection and inflammation of bone marrow, often progresses to chronic stage because of delay in diagnosis and treatment. Once it becomes chronic, intravenous antibiotics therapy is no longer effective as swollen surrounding tissue interrupts blood flow into the infected tissue. In severe cases, debridement of the necrotic tissue becomes necessary to prevent further infection. In this study, for the first time, we produced three-dimensional (3D) printed antibiotics-loaded biodegradable poly-ε-caprolactone/poly(lactic-co-glycolic acid) scaffold for treatment of chronic osteomyelitis. Subsequent bone regeneration in debrided site was also observed with the customized scaffolds fabricated using 3D printing. Tobramycin, one of the most widely used antibiotics in orthopedic surgery, was chosen due to its thermostable nature compliant to the heat-based fabrication conditions. In in vitro tests, antibacterial and anti-inflammatory effects and release profile of tobramycin from the scaffold were evaluated to verify the potential of our scaffold as a drug delivery system. In addition, in vivo efficacy of the developed drug loaded scaffolds for treatment of chronic osteomyelitis was also examined in a rat model.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Lew DP / 2004 / Osteomyelitis / Lancet 364:369~379
Concia E / 2006 / Osteomyelitis : clinical update for practical guidelines / Nucl Med Commun 27:645~660
Patzakis MJ / 2005 / Chronic posttraumatic osteomyelitis and infected nonunion of the tibia : current management concepts / J Am Acad Orthop Surg 13:417~427
Jia WT / 2010 / Novel borate glass/chitosan composite as a delivery vehicle for teicoplanin in the treatment of chronic osteomyelitis / Acta Biomater 6:812~819
Hansen T / 2006 / Osteonecrosis of the jaws in patients treated with bisphosphonates-histomorphologic analysis in comparison with infected osteoradionecrosis / J Oral Pathol Med 35:155~160
Concia E / 2006 / Osteomyelitis : clinical update for practical guidelines / Nucl Med Commun 27:645~660
Patzakis MJ / 2005 / Chronic posttraumatic osteomyelitis and infected nonunion of the tibia : current management concepts / J Am Acad Orthop Surg 13:417~427
Jia WT / 2010 / Novel borate glass/chitosan composite as a delivery vehicle for teicoplanin in the treatment of chronic osteomyelitis / Acta Biomater 6:812~819
Hansen T / 2006 / Osteonecrosis of the jaws in patients treated with bisphosphonates-histomorphologic analysis in comparison with infected osteoradionecrosis / J Oral Pathol Med 35:155~160
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