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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 537 - 548 (12page)
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Background: Human adipose-derived mesenchymal stem cells (AMSCs) are an attractive resource for wound healing because their regenerative capacity improves injury repair. Recently, stem cell-derived exosomes have been shown to play a positive role in stem cell-based therapies. However, the effects of exosomes derived from AMSCs (AEXOs) on wound healing are unclear. In this study, we aimed to examine the role of AEXOs in attenuating inflammation and explore their effects in normal wound healing. Methods: We isolated exosomes from AMSCs and established a cellular model of inflammation by treatment with the inflammatory cytokines, interferon gamma and tumor necrosis factor alpha, to determine whether AEXOs can inhibit inflammation. We examined the wound healing effects of AEXOs in in vitro wound healing models and performed a miRNA array to understand the role of AEXOs in inflammation and wound healing. Results: A significant difference was observed in wound closure and the expression of anti-inflammatory and wound-healing-related factors between control and AEXO-treated cells. Conclusion: Our results showed that besides alleviating the inflammation response, AEXOs also promote wound healing. Thus, AEXOs represent a novel, stem-cell-based, therapeutic strategy for wound healing.
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참고문헌 (47)
참고문헌 신청
Rodriguez-Menocal L / 2012 / Stimulation of skin and wound fibroblast migration by mesenchymal stem cells derived from normal donors and chronic wound patients / Stem Cells Transl Med 1:221~229
Zhao P / 2017 / Antiaging pharmacology in cutaneous wound healing : effects of metformin, resveratrol, and rapamycin by local application / Aging Cell 16:1083~1093
Martin P / 1997 / Wound healing–aiming for perfect skin regeneration / Science 276:75~81
Kim SY / 2019 / Macrophages in wound healing : activation and plasticity / Immunol Cell Biol 97:258~267
Yoon D / 2018 / Accelerated wound healing by fibroblasts differentiated from human embryonic stem cell-derived mesenchymal stem cells in a pressure ulcer animal model / Stem Cells Int 2018:4789568
Zhao P / 2017 / Antiaging pharmacology in cutaneous wound healing : effects of metformin, resveratrol, and rapamycin by local application / Aging Cell 16:1083~1093
Martin P / 1997 / Wound healing–aiming for perfect skin regeneration / Science 276:75~81
Kim SY / 2019 / Macrophages in wound healing : activation and plasticity / Immunol Cell Biol 97:258~267
Yoon D / 2018 / Accelerated wound healing by fibroblasts differentiated from human embryonic stem cell-derived mesenchymal stem cells in a pressure ulcer animal model / Stem Cells Int 2018:4789568
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