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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 695 - 704 (10page)
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Background: Mannitol increases blood–brain barrier permeability and can improve the efficiency of systemically administered stem cells by facilitating stem cell entry from the periphery into the injured brain. The aim of this study was to elucidate the neuroprotective effects of a combination of mannitol pretreatment and stem cell transplantation on stroke-induced neural injury. Methods: The experimental rats were randomly assigned to three groups 24 h after middle cerebral artery occlusion and reperfusion. One group received intravenous (IV) injections of phosphate-buffered saline (vehicle), another group received IV injections of human adipose-derived stem cells (hADSCs), and the last group received IV injections of hADSCs 10 min after IV mannitol injections. Neurobehavioral functions and infarct volume were compared. Immunohistochemistry (IHC) analyses were performed using antibodies against ionized calcium binding adapter-1 (IBA-1), rat endothelial antigen-1 (RECA-1), and bromodeoxyuridine/doublecortin (BrdU/DCX). Results: PKH-26 labeling revealed no difference in the number of stem cells that had migrated into the injured brain, and hADSC transplantation did not improve the infarct volume. However, neurobehavioral functions improved in the mannitol group. IHC showed higher numbers of RECA-1-positive cells in the peri-infarcted brain and BrdU-/DCX-colocalized cells in the subventricular zone in the mannitol group. IBA-1-positive cell number decreased in the hADSC-only and mannitol-pretreatment groups compared with the vehicle group even though there was no difference between the former two groups. Conclusion: Combinatorial treatment with mannitol and hADSC transplantation may have better therapeutic potential than hADSC monotherapy for ischemic stroke.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Feigin VL / 2014 / Global and regional burden of stroke during 1990–2010 : findings from the Global Burden of Disease Study 2010 / Lancet 383:245~254
Norrving B / 2013 / The global burden of stroke and need for a continuum of care / Neurology 80:S5~S12
Ovbiagele B / 2013 / Forecasting the future of stroke in the United States : a policy statement from the American Heart Association and American Stroke Association / Stroke 44:2361~2375
Nogueira RG / 2018 / Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct / N Engl J Med 378:11~21
Powers WJ / 2019 / Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 50:e344~e418
Norrving B / 2013 / The global burden of stroke and need for a continuum of care / Neurology 80:S5~S12
Ovbiagele B / 2013 / Forecasting the future of stroke in the United States : a policy statement from the American Heart Association and American Stroke Association / Stroke 44:2361~2375
Nogueira RG / 2018 / Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct / N Engl J Med 378:11~21
Powers WJ / 2019 / Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 50:e344~e418
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