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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 7 (7page)
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Dysregulated receptor tyrosine kinase signaling in human cancer cells leads to tumor progression, invasion and metastasis. The receptor tyrosine kinase cMET is frequently overexpressed in cancer tissue, and activation of cMET signaling is related to drug resistance and the processes of carcinogenesis, invasion and metastasis. For that reason, cMET and its ligand, hepatocyte growth factor (HGF), are considered prime targets for the development of anticancer drugs. At least eight anti-cMET and four anti-HGF antibodies have been tested or are being tested in clinical trials. However, to date none of these HGF/cMET inhibitors have shown significant efficacy in clinical trials. Furthermore, no receptor tyrosine kinase inhibitors primarily targeting cMET have been approved. Given that neutralization of HGF or cMET does not cause significant adverse effects, inhibition of the HGF/cMET signaling pathway appears to be safe. In this review, we summarized the completed and ongoing clinical trials testing antibody- or protein-based anticancer drugs targeting cMET and HGF.
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참고문헌 (24)
참고문헌 신청
Bean J / 2007 / MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib / Proc Natl Acad Sci U
Birchmeier C / 2003 / Met, metastasis, motility and more / Nat Rev Mol Cell Biol 4 : 915 ~ 925
Blumenschein GR / 2012 / Targeting the hepatocyte growth factor-cMET axis in cancer therapy / J Clin Oncol 30 : 3287 ~ 3296
Christensen JG / 2005 / c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention / Cancer Lett 225 : 1 ~ 26
Comoglio PM / 2008 / Drug development of MET inhibitors : targeting oncogene addiction and expedience / Nat Rev Drug Discov 7 : 504 ~ 516
Birchmeier C / 2003 / Met, metastasis, motility and more / Nat Rev Mol Cell Biol 4 : 915 ~ 925
Blumenschein GR / 2012 / Targeting the hepatocyte growth factor-cMET axis in cancer therapy / J Clin Oncol 30 : 3287 ~ 3296
Christensen JG / 2005 / c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention / Cancer Lett 225 : 1 ~ 26
Comoglio PM / 2008 / Drug development of MET inhibitors : targeting oncogene addiction and expedience / Nat Rev Drug Discov 7 : 504 ~ 516
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A human antibody against human endothelin receptor type A that exhibits antitumor potency
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3D Cancer Cell Chip for the Detection of Anticancer Drug Effects
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D-Tyrosine-based Peptide Assembly for Tyrosinase Inhibitor
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