Current Progress in Tendon and Ligament Tissue Engineering

Wei Lee Lim; Ling Ling Liau; Min Hwei Ng; Shiplu Roy Chowdhury; Jia Xian Law

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자료유형: 학술저널

저자정보: Wei Lee Lim (Universiti Kebangsaan Malaysia Medical Centre) Ling Ling Liau (Universiti Kebangsaan Malaysia Medical Centre) Min Hwei Ng (Universiti Kebangsaan Malaysia Medical Centre) Shiplu Roy Chowdhury (Universiti Kebangsaan Malaysia Medical Centre) Jia Xian Law (Universiti Kebangsaan Malaysia Medical Centre)

저널정보: 한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제16권 제6호

발행연도: 2019.1

수록면: 549 - 571 (23page)

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BACKGROUND: Tendon and ligament injuries accounted for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year and thus imposed a significant burden to the society and the economy. Damaged tendon and ligament can severely affect the normal body movement and might lead to many complications if not treated promptly and adequately. Current conventional treatment through surgical repair and tissue graft are ineffective with a high rate of recurrence. METHODS: In this review, we first discussed the anatomy, physiology and pathophysiology of tendon and ligament injuries and its current treatment. Secondly, we explored the current role of tendon and ligament tissue engineering, describing its recent advances. After that, we also described stem cell and cell secreted product approaches in tendon and ligament injuries. Lastly, we examined the role of the bioreactor and mechanical loading in in vitro maturation of engineered tendon and ligament. RESULTS: Tissue engineering offers various alternative ways of treatment from biological tissue constructs to stem cell therapy and cell secreted products. Bioreactor with mechanical stimulation is instrumental in preparing mature engineered tendon and ligament substitutes in vitro. CONCLUSIONS: Tissue engineering showed great promise in replacing the damaged tendon and ligament. However, more study is needed to develop ideal engineered tendon and ligament.

#Tendon Ligament Tissue engineering Stem cell Bioreactor Exosomes

참고문헌 (194)

참고문헌 신청

Yang G / 2013 / Tendon and ligament regeneration and repair : clinical relevance and developmental paradigm / Birth Defects Res C Embryo Today 99:203~222

Chainani A / 2013 / Multilayered electrospun scaffolds for tendon tissue engineering / Tissue Eng Part A 19:2594~2604

Docheva D / 2015 / Biologics for tendon repair / Adv Drug Deliv Rev 84:222~239

Dhammi IK / 2015 / Graft choices for anterior cruciate ligament reconstruction / Indian J Orthop 49:127~128

Chen T / 2015 / Status and headway of the clinical application of artificial ligaments / Asia Pac J Sports Med Arthrosc Rehabil Technol 2:15~26

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