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논문 기본 정보

자료유형
학술저널
저자정보
Zahra Rashidbenam (Universiti Kebangsaan Malaysia Medical Centre) Mohd Hafidzul Jasman (Universiti Kebangsaan Malaysia Medical Centre) Pezhman Hafez (UCSI University) Guan Hee Tan (Universiti Kebangsaan Malaysia Medical Centre) Eng Hong Goh (Departments of Surgery Universiti Kebangsaan Malaysia Medical Center) Xeng Inn Fam (Departments of Surgery Universiti Kebangsaan Malaysia Medical Center) Christopher Chee Kong Ho (School of Medicine Taylor’s University) Zulkifli Md Zainuddin (Universiti Kebangsaan Malaysia) Reynu Rajan (Universiti Kebangsaan Malaysia Medical Centre) Fatimah Mohd Nor (Universiti Kebangsaan Malaysia Medical Centre) Mohamad Aznan Shuhaili (Universiti Kebangsaan Malaysia Medical Centre) Nik Ritza Kosai (Universiti Kebangsaan Malaysia Medical Centre) Farrah-Hani Imran (University Kebangsaan Malaysia Medical Centre) Min Hwei Ng (Universiti Kebangsaan Malaysia Medical Centre)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제16권 제4호
발행연도
2019.1
수록면
365 - 384 (20page)

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BACKGROUND: Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral dilation and urethrotomy; but in cases of long urethral strictures, substitution urethroplasty with genital skin and buccal mucosa grafts is the only option. However a number of complications such as infection as a result of hair growth in neo-urethra, and stone formation restrict the application of those grafts. Therefore, tissue engineering techniques recently emerged as an alternative approach, aiming to overcome those restrictions. The aim of this review is to provide a comprehensive coverage on the strategies employed and the translational status of urethral tissue engineering over the past years and to propose a combinatory strategy for the future of urethral tissue engineering. METHODS: Data collection was based on the key articles published in English language in years between 2006 and 2018 using the searching terms of urethral stricture and tissue engineering on PubMed database. RESULTS: Differentiation of mesenchymal stem cells into urothelial and smooth muscle cells to be used for urologic application does not offer any advantage over autologous urothelial and smooth muscle cells. Among studied scaffolds, synthetic scaffolds with proper porosity and mechanical strength is the best option to be used for urethral tissue engineering. CONCLUSION: Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a prevascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra.
#Scaffold Tissue engineering Urethral stricture Urethral reconstruction

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참고문헌 (77)

참고문헌 신청
Orabi H / 2013 / Tissue engineering of urinary bladder and urethra : advances from bench to patients / ScientificWorldJournal 2013:154564 google schola Orabi H / 2014 / Cells and biomaterials in regenerative medicine / IntechOpen google schola Chung YG / 2014 / Acellular bi-layer silk fibroin scaffolds support tissue regeneration in a rabbit model of onlay urethroplasty / PLoS One 9:e91592 google schola de Kemp V / 2015 / Tissue engineering for human urethral reconstruction : systematic review of recent literature / PLoS One 10:e0118653 google schola Raya-Rivera A / 2011 / Tissue-engineered autologous urethras for patients who need reconstruction : an observational study / Lancet 377:1175~1182 google schola

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