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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 9 (9page)
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BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure leukaemia. However, long term complications of post transplantation interfere with the patients’ full recovery. The objective of this review was to identify the various long term complications and to assess their individual prevalences. METHODS: Electronic databases including PubMed, Google Scholar and Cochrane were searched for years 2004–2017. The keywords used were leukaemia, allogenic stem cell transplantation, prevalence, side effects, long term, delayed, adverse effects, complications and outcome. RESULTS: A total of ten articles were included for analysis. There were 5 prospective studies, 3 retrospective studies and 2 cross sectional studies. A total of 40,069 patients, (20,189 males and 17,191 females) participated in these 10 studies. The gender of 2689 patients were not disclosed. Most common late complications and prevalence were chronic graft versus host disease (43% at 5 years post HSCT), secondary tumor (21% at 20 years post HSCT), hypothyroidism (11% at 15 years), bronchiolitis obliterans (9.7% at 122 days), cardiovascular disease (7.5% at 15 years) and avascular necrosis (5.4% at 10 years). The prevalence of azoospermia was 71.1% and depression, 18%. For the latter two conditions no time limit was available. Follow up duration ranged from 2 years till 30 years post HSCT. CONCLUSION: While allogenic stem cell transplantation is an effective cure for leukaemia, the procedure is associated with complications that can have their onset many years after the procedure.
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참고문헌 (32)
참고문헌 신청
Antin JH / 2002 / Clinical practice. Long-term care after hematopoieticcell transplantation in adults / Engl J Med 347:36~42
Rizzo JD / 2009 / Solid cancers after allogenic heamatopoietic stem cell transplantation / Blood 113:1175~1183
Mohty M / 2010 / Long-term physiological side effects after allogeneic bone marrow transplantation / Hematol Am Soc Hematol Educ Program 2010:229~236
Nivison-Smith I / 2009 / Relative survival of long-term hematopoietic cell transplant recipients approaches general population rates / Biol Blood Marrow Transplant 15:1323~1330
Martin PJ / 2010 / Life expectancy in patients surviving more than 5 years after haemopoietic cell transplantation / J Clin Oncol 28:1011~1016
Rizzo JD / 2009 / Solid cancers after allogenic heamatopoietic stem cell transplantation / Blood 113:1175~1183
Mohty M / 2010 / Long-term physiological side effects after allogeneic bone marrow transplantation / Hematol Am Soc Hematol Educ Program 2010:229~236
Nivison-Smith I / 2009 / Relative survival of long-term hematopoietic cell transplant recipients approaches general population rates / Biol Blood Marrow Transplant 15:1323~1330
Martin PJ / 2010 / Life expectancy in patients surviving more than 5 years after haemopoietic cell transplantation / J Clin Oncol 28:1011~1016
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