지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Infectious diseases, including coronavirus disease 2019 (COVID-19), are representative, of which etiology is known in all human diseases. However, many enigmas persist in relation to COVID-19, including different clinical phenotypes and incubation periods across individuals, species-specificity, appearance of cytokine storm and lymphopenia, and the mechanism of damage to organ cells. Current immunological concepts have limitations to explain these unsolved issues. Meanwhile, results of clinical, pathological, and animal studies have suggested that the virus itself is not a direct cause of acute injury to the lung or other organ cells. For better understanding of COVID-19, a presumed immunopathogenesis of COVID-19 is presented under the protein-homeostasis-system hypothesis; every disease, including COVID-19, has associated etiological substances, and the host immune system controls these diverse substances according to the size and biochemical property. These etiological substances, inducing inflammation and subsequent tissue injury, are smaller substances derived from virus-infected cells. Initially acting nonspecific adaptive immune reaction with cytokine imbalance may be responsible for target cell injury. Furthermore, substances from initial target cell injury and secondary bacterial invasion can induce further inflammation if released from local or systemic circulation. COVID-19 patients with pneumonia show hypercytokinemia with lymphocytopenia corresponding to the severity of pneumonia at early stages. Thus, early immune-modulator treatment, including corticosteroids and intravenous immunoglobulin, has an immunological rationale. It could help reduce the morbidity and possibly mortality of older patients with underlying conditions.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
World Health Organization / Coronavirus disease 2019 (COVID-19) situation report-53
이경일 / 2015 / A Common Immunopathogenesis Mechanism for Infectious Diseases: The Protein-Homeostasis-System Hypothesis / Infection and Chemotherapy 47(1):12~26
Shryock RH / 1936 / The development of modern medicine : an interpretation of the social and scientific factors involved / University of Pennsylvania Press
Liu Z / 2015 / Immune homeostasis enforced by co-localized effector and regulatory T cells / Nature 528:225~230
Fehr AR / 2015 / Coronaviruses : an overview of their replication and pathogenesis. Version 2 / Methods Mol Biol 1282:1~23
이경일 / 2015 / A Common Immunopathogenesis Mechanism for Infectious Diseases: The Protein-Homeostasis-System Hypothesis / Infection and Chemotherapy 47(1):12~26
Shryock RH / 1936 / The development of modern medicine : an interpretation of the social and scientific factors involved / University of Pennsylvania Press
Liu Z / 2015 / Immune homeostasis enforced by co-localized effector and regulatory T cells / Nature 528:225~230
Fehr AR / 2015 / Coronaviruses : an overview of their replication and pathogenesis. Version 2 / Methods Mol Biol 1282:1~23
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