메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

The Discovery of Clinically Applicable Biomarkers for Bipolar Disorder: A Review of Candidate and Proteomic Approaches
Recommendations
Search

논문 기본 정보

Type
Academic journal
Author
Ather Muneer (Riphah International University)
Journal
Chonnam University Research Institute of Medical Science 전남의대학술지 전남의대학술지 제56권 제3호 KCI Accredited Journals
Published
2020.1
Pages
166 - 179 (14page)

Usage

cover
The Discovery of Clinically Applicable Biomarkers for Bipolar Disorder: A Review of Candidate and Proteomic Approaches
Ask AI
Recommendations
Search

Abstract· Keywords

Report Errors
Bipolar disorder (BD) is a severe psychiatric condition which affects innumerable people across the globe. The etiopathogenesis of BD is multi-faceted with genetic, environmental and psychosocial factors playing a role. Hitherto, the diagnosis and management of BD are purely on empirical grounds as we lack confirmed biomarkers for this condition. In this regard, hypothesis-driven investigations have been unable to identify clinically applicable biomarkers, steering the field towards newer technologies. Innovative, state-of-the-art techniques like multiplex immunoassays and mass spectrometry can potentially investigate the entire proteome. By detecting up or down regulated proteins, novel biomarkers are identified and new postulates about the etiopathogenesis of BD are specified. Hence, biological pathways are uncovered which are involved in the initiation and advancement of the disease and new therapeutic targets are identified. In this manuscript, the extant literature is thoroughly reviewed and the latest findings on candidate BD biomarkers are provided, followed by an overview of the proteomic approaches. It was found that due to the heterogeneous nature of BD no single biomarker is feasible, instead a panel of tests is more likely to be useful. With the application of latest technologies, it is expected that validated biomarkers will be discovered which will be useful as diagnostic tools and help in the delivery of individually tailored therapies to the patients.
#Biomarkers #Bipolar Disorder #Proteomics #Mass Spectrometry

Contents

No content found

References (84)

Add References
Joslyn C / 2016 / Is age of onset associated with severity, prognosis, and clinical features in bipolar disorder? A meta-analytic review / Bipolar Disord 18:389~403 google schola Solé E / 2017 / Mixed features in bipolar disorder / CNS Spectr 22:134~140 google schola Ather Muneer / 2018 / The Staging of Major Mood Disorders: Clinical and Neurobiological Correlates / PSYCHIATRY INVESTIGATION 15(8):747~758 dbpia Gigante AD / 2016 / Psychiatric and clinical correlates of rapid cycling bipolar disorder : a cross-sectional study / Braz J Psychiatry 38:270~274 google schola Perugi G / 2015 / The use of stimulants and atomoxetine in adults with comorbid ADHD and bipolar disorder / Expert Opin Pharmacother 16:2193~2204 google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

An Analysis on the Legal Issues of the EBS-Linked KSAT Policy: Focusing on the Constitutional Court’s Decision
Lina Kim, Eom, Moonyoungundefined2024.08
 A Brief Review on the Negative Effects of Simplified Chinese Characters on Chinese Character Education
Kim, Jun-soo2018
 Erratum to: Coronary Circulation; Macro or Micro, That Is the Question
구본권 , BonKwonThe Korean Society of Cardiology2015
 1990~1999년 일본 일간지의 혐한 담론 표상 방식
노윤선The Japanese Language And Literature Society Of Korea2021.04

Comments(0)

0

Write first comments.