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논문 기본 정보

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저자정보
Sanchit Sharma (All India Institute of Medical Sciences) Arti Gupta (All India Institute of Medical Sciences) Saurabh Kedia (All India Institute of Medical Sciences) Samagra Agarwal (All India Institute of Medical Sciences) Namrata Singh (All India Institute of Medical Sciences) Sandeep Goyal (All India Institute of Medical Sciences) Saransh Jain (All India Institute of Medical Sciences) Vipin Gupta (All India Institute of Medical Sciences) Pabitra Sahu (All India Institute of Medical Sciences) Sudheer Kumar Vuyyuru (All India Institute of Medical Sciences) Bhaskar Kante (All India Institute of Medical Sciences) Raju Sharma (All India Institute of Medical Sciences New Delhi) Rajesh Panwar (All India Institute of Medical Sciences) Peush Sahni (All India Institute of Medical Sciences) Govind Makharia (All India Institute of Medical Sciences) Vineet Ahuja (All India Institute of Medical Sciences)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.19 No.3
발행연도
2021.1
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291 - 300 (10page)

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Background/Aims: Exclusive enteral nutrition (EEN), an established modality for pediatric Crohn’s disease (CD) is seldomly utilized in adults. The present study reports the outcome of EEN in adult CD patients at a tertiary care hospital in India.Methods: This was a retrospective analysis of CD patients who received EEN as a sole modality/adjunct to other treatment. The primary and secondary outcomes changed in Crohn’s Disease Activity Index (CDAI), and clinical response (decline in CDAI > 70), respectively, at 4 and 8 weeks. Subgroup analysis evaluated response across different phenotypes, EEN formulations and prior treatment. Linear mixed effect model was created to assess the predictors of EEN response.Results: Thirty-one CD patients received EEN over median duration of 4 weeks (range, 2–6 weeks). CDAI showed a significant improvement post EEN at 4 (baseline 290 [260–320] vs. 240 [180–280], <i>P</i>= 0.001) and 8 weeks (baseline 290 [260–320] vs. 186 [160–240], <i>P</i>= 0.001), respectively. The cumulative clinical response rates at 4 and 8 weeks were 37.3% and 80.4% respectively. The clinical response rates at 8 weeks across B1 (n = 4), B2 (n = 18) and B3 (n = 9) phenotypes were 50%, 78.8% and 100% respectively (log-rank test, <i>P</i>= 0.093). The response rates at 8 weeks with polymeric (n = 8) and semi-elemental diet (n = 23) were 75% and 82.6%% respectively (log-rank test, <i>P</i>= 0.49). Baseline CDAI (odds ratio, 1.008; 95% confidence interval, 1.002–1.017; <i>P</i>= 0.046) predicted response to EEN.Conclusions: EEN was effective in inducing clinical response across different phenotypes of CD. Baseline disease activity remained the most important predictor of clinical response to EEN.
#Exclusive enteral nutrition #Crohn disease #Crohn's Disease Activity Index #Inflammation

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참고문헌 (37)

참고문헌 신청
Torres J / 2017 / Crohn’s disease / Lancet 389:1741~1755 google schola Amre DK / 2007 / Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn’s disease in children / Am J Gastroenterol 102:2016~2025 google schola Lee D / 2015 / Diet in the pathogenesis and treatment of inflammatory bowel diseases / Gastroenterology 148:1087~1106 google schola Knight-Sepulveda K / 2015 / Diet and inflammatory bowel disease / Gastroenterol Hepatol(N Y) 11:511~520 google schola Sugihara K / 2019 / The role of dietary nutrients in inflammatory bowel disease / Front Immunol 9:3183 google schola

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