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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 421 - 429 (9page)
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Background/Aims: Ulcerative colitis (UC), along with Crohn’s disease, is one of the main types of inflammatory bowel disease (IBD). On the other hand, deregulated autophagy is involved in many chronic diseases, including IBD. In this study, we aimed to investigate the role of Atg5 and microRNA-181a (miR-181a) in the pathophysiology of UC. Methods: Colon biopsy, stool, and blood samples of 6 men and 9 women were confirmed for UC. Also, 13 men and 17 women were selected as healthy control (HC). Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry were used to measure the Atg-5 content of the colon biopsies. Besides, the serum and stool levels of Atg5 were measured using ELISA. Moreover, the total RNA of blood cells was extracted and evaluated for the expression of miR-181a.Results: We found 1.2 ng/mL versus 0.46 ng/mL, 0.34 ng/mL versus 0.24 ng/mL, and 0.082 ng/mL versus 0.062 ng/mL of Atg5 in stool, intestinal tissue, and serum of UC and HCs, respectively. There was no significant difference in the expression of miR-181a in the blood samples of UC and HCs. Immunohistochemistry showed high positivity without any significant difference between the 2 groups in the quantitative analysis.Conclusions: The significant difference observed between the stool Atg5 content of the HCs and UC patients may provide new insight into using this protein as a diagnostic biomarker, however, considering the small size of our studied population further studies are needed.
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참고문헌 (43)
참고문헌 신청
Hosseini SV / 2016 / Incidence of ulcerative colitis relapse : a prospective cohort study in southern Iran / Ann Colorectal Res 4:e34565
Iida T / 2017 / Role of autophagy in the pathogenesis of inflammatory bowel disease / World J Gastroenterol 23:1944~1953
Sartor RB / 2012 / Intestinal microbes in inflammatory bowel diseases / Am J Gastroenterol Suppl 1:15
Cosnes J / 2011 / Epidemiology and natural history of inflammatory bowel diseases / Gastroenterology 140:1785~1794
Ramsey M / 2017 / Inflammatory bowel disease adversely impacts colorectal cancer surgery short-term outcomes and health-care resource utilization / Clin Transl Gastroenterol 8:e127
Iida T / 2017 / Role of autophagy in the pathogenesis of inflammatory bowel disease / World J Gastroenterol 23:1944~1953
Sartor RB / 2012 / Intestinal microbes in inflammatory bowel diseases / Am J Gastroenterol Suppl 1:15
Cosnes J / 2011 / Epidemiology and natural history of inflammatory bowel diseases / Gastroenterology 140:1785~1794
Ramsey M / 2017 / Inflammatory bowel disease adversely impacts colorectal cancer surgery short-term outcomes and health-care resource utilization / Clin Transl Gastroenterol 8:e127
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