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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 282 - 288 (7page)
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Background/Aims: Safety for tumor necrosis factor inhibitors (TNFi) in cancer has been focused on risk of incident malignancies, but studies on prognostic effects have been scarce. We determined survival and recurrence rates at 1, 2, and 5 years after cancer diagnosis in patients with and without concurrent TNFi use.Methods: Chart reviews were performed between 1996 and 2015 at the VA North Texas Healthcare System. Cases were patients with inflammatory disease, concomitant malignancy, and TNFi use while controls were patients with inflammatory disease, concomitant malignancy but no TNFi use. Cases and controls were matched for type of malignancy. Analysis was performed with log-rank tests on Kaplan-Meier curves.Results: Thirty-six cases and 72 controls were identified. For cases, survival at 1, 2, and 5 years were 32 (89%), 31 (86%), and 29 (81%) compared to 63 (90%), 61 (87%), and 51 (73%) for the control group (<i>P</i>=0.985). For cases, recurrence rates at 1, 2, and 5 years were 3 (8%), 5 (14%), and 6 (17%) compared to 2 (3%), 5 (7%), and 7 (10%) for the control group (<i>P</i>=0.158). Conclusions: Our findings suggest TNFi may be safely used in select inflammatory disease patients with concurrent cancer if therapy is needed for proper disease control. However, case-by-case consideration in conjunction with an oncologist is recommended while considering the apparent safety of TNFi for patients suffering from active inflammatory diseases despite having a concomitant malignancy.
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참고문헌 (11)
참고문헌 신청
Elandt K / 2011 / Treating rheumatic patients with a malignancy / Arthritis Res Ther 13:223
Nguyen GC / 2016 / First do no harm: is it safe to use immunosuppressants in inflammatory bowel disease patients with prior cancer? / Gastroenterology 151:22~24
Penn I / 1997 / Evaluation of transplant candidates with pre-existing malignancies / Ann Transplant 2:14~17
Center for Drug Evaluation and Research / Drug Safety Information for Heathcare Professionals - Questions and Answers - TNF Blockers 8/25/2009
Bongartz T / 2006 / Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies : systematic review and meta-analysis of rare harmful effects in randomized controlled trials / JAMA 295:2275~2285
Nguyen GC / 2016 / First do no harm: is it safe to use immunosuppressants in inflammatory bowel disease patients with prior cancer? / Gastroenterology 151:22~24
Penn I / 1997 / Evaluation of transplant candidates with pre-existing malignancies / Ann Transplant 2:14~17
Center for Drug Evaluation and Research / Drug Safety Information for Heathcare Professionals - Questions and Answers - TNF Blockers 8/25/2009
Bongartz T / 2006 / Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies : systematic review and meta-analysis of rare harmful effects in randomized controlled trials / JAMA 295:2275~2285
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