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논문 기본 정보

자료유형
학술저널
저자정보
Ji Yeon Kim (Mediplex Sejong Hospital) Sungkyoung Choi (Seoul National University) Taesung Park (Seoul National University) Seul Ki Kim (Kangbuk Samsung Hospital) Yoon Suk Jung (Kangbuk Samsung Hospital) Jung Ho Park (Kangbuk Samsung Hospital) Hong Joo Kim (Kangbuk Samsung Hospital) Yong Kyun Cho (Kangbuk Samsung Hospital) Chong Il Sohn (Kangbuk Samsung Hospital) 전우규 (성균관대학교) 김병익 (성균관대학교) Kyu Yong Choi (Kangbuk Samsung Hospital) 박동일 (성균관대학교)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.17 No.2
발행연도
2019.1
수록면
253 - 264 (12page)

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Background/Aims: Colorectal cancer incidence among patients aged ≤50 years is increasing. This study aimed to develop and validate an advanced colorectal neoplasm (ACRN) screening model for young adults aged <50 years in Korea. Methods: This retrospective cross-sectional study included 59,575 consecutive asymptomatic Koreans who underwent screening colonoscopy between 2003 and 2012 at a single comprehensive health care center. Young Adult Colorectal Screening (YCS) score was developed as an optimized risk stratification model for ACRN using multivariate analysis and was internally validated. The predictive power and diagnostic performance of YCS score was compared with those of Asia-Pacific Colorectal Screening (APCS) and Korean Colorectal Screening (KCS) scores. Results: 41,702 and 17,873 subjects were randomly allocated into the derivation and validation cohorts, respectively, by examination year. ACRN prevalence was 0.9% in both cohorts. YCS score comprised sex, age, alcohol, smoking, obesity, glucose metabolism abnormality, and family history of CRC, with score ranges of 0 to 10. In the validation cohort, ACRN prevalence was 0.6% in the low-risk tier (score, 0–4), 1.5% in the moderate-risk tier (score, 5–7), and 3.4% in the high-risk tier (score, 8–10). ACRN risk increased 2.5-fold (95% confidence interval [CI], 1.8–3.4) in the moderate-risk tier and 5.8-fold (95% CI, 3.4–9.8) in the high-risk tier compared with the low-risk tier. YCS score identified better balanced accuracy (53.9%) than APCS (51.5%) and KCS (50.7%) scores and had relatively good discriminative power (area under the curve=0.660). Conclusions: YCS score based on clinical and laboratory risk factors was clinically effective and beneficial for predicting ACRN risk and targeting screening colonoscopy in adults aged <50 years. (Intest Res 2019;17:253-264)

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