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논문 기본 정보

자료유형
학술저널
저자정보
강은애 (Seoul National University College of Medicine) Seung Jun Han (Seoul National University College of Medicine) Jaeyoung Chun (Seoul National University College of Medicine) Hyun Jung Lee (Seoul National University College of Medicine) Hyunsoo Chung (Seoul National University College of Medicine) Jong Pil Im (Seoul National University College of Medicine) Sang Gyun Kim (Seoul National University College of Medicine) 김주성 (서울대학교) Hyuk Yoon (Seoul National University Bundang Hospital) Cheol Min Shin (Seoul National University Bundang Hospital) Young Soo Park (Seoul National University Bundang Hospital) Nayoung Kim (Seoul National University Bundang Hospital) Dong Ho Lee (Seoul National University Bundang Hospital) Hyun Chae Jung (Seoul National University College of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.17 No.1
발행연도
2019.1
수록면
135 - 143 (9page)

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Background/Aims: Spontaneous intramural small bowel hematoma (SISBH) is an extremely rare complication of anticoagulant or antiplatelet therapy. We assessed the clinical characteristics and outcomes of patients with SISBH according to the anatomical location of the hematoma. Methods: From January 2003 to February 2016, medical records for all patients hospitalized for SISBH at 2 tertiary referral hospitals were retrospectively reviewed. The primary outcome was requirement for surgery. Results: A total of 37 patients were enrolled. The mean age was 74.1 years. Among them, 33 patients (89.2%) were taking anticoagulant and/or antiplatelet agents. Duodenal intramural hematoma was detected in 4 patients (10.8%), jejunal in 16 (43.2%), and ileal in 17 (45.9%). Compared to jejunal and ileal involvement, duodenal intramural hematoma was significantly associated with high Charlson comorbidity index and low levels of white blood cells, hemoglobin, and platelets in the blood. SISBH in the duodenum was related to thrombocytopenia in 3 patients following systemic chemotherapy for malignancy. All patients with SISBH showed clinical improvement with conservative therapy. Mean length of hospital stay was 9.35 days. Independent predictors of a hospital stay of more than 7 days were body weight less than 60 kg (odds ratio [OR], 12.213; 95% confidence interval [CI], 1.755–84.998; P=0.011) and a history of cerebrovascular accidents (OR, 6.667; 95% CI, 1.121–39.650; P=0.037). Conclusions: Compared to jejunal and ileal involvement, thrombocytopenia may result in spontaneous duodenal intramural hematoma among patients who are treated with systemic chemotherapy for malignancies. Patients with SISBH have excellent clinical outcomes with conservative therapy regardless of the anatomical location of the hematoma. (Intest Res 2019;17:135-143)

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