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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 279 - 289 (11page)
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초록· 키워드
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The airway mucosa is the first point of exposure to all inhalant materials. It is possible to produce microenvironments functionally similar to airway by using different types of extracellular matrices around mucosal cells, such as an extracellular matrix decellularized from trachea. In this study, we introduced a novel human respiratory mucosa-on-achip model that uses decellularized tracheal extracellular matrix to assess functional similarities. We also evaluated the effects of respiratory toxicant based on changes in cell viability, tight junction function, oxidative stress, expression of cell adhesion proteins in the vascular network, mucous secretion, and inflammatory cytokine secretion after treatment. This novel human respiratory mucosa-on-a-chip model is expected to be useful for assessing respiratory mucosa reactions to external bacteria or viruses and inhaled drugs.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Fokkens, W. J. / 2020 / European Position Paper on Rhinosinusitis and Nasal Polyps 2020 / Rhinology 58:1~464
Heijink, I. H. / 2014 / Airway epithelial barrier function regulates the pathogenesis of allergic asthma / Clin. Exp. Allergy 44:620~630
Carrabino, S. / 2006 / Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells / J. Cystic Fibrosis 5:113~119
Stecenko, A. A. / 2001 / Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells / Inflammation 25:145~155
Van Bruaene, N. / 2008 / T-cell regulation in chronic paranasal sinus disease / J. Allergy Clin. Immunol 121:1435~1441
Heijink, I. H. / 2014 / Airway epithelial barrier function regulates the pathogenesis of allergic asthma / Clin. Exp. Allergy 44:620~630
Carrabino, S. / 2006 / Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells / J. Cystic Fibrosis 5:113~119
Stecenko, A. A. / 2001 / Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells / Inflammation 25:145~155
Van Bruaene, N. / 2008 / T-cell regulation in chronic paranasal sinus disease / J. Allergy Clin. Immunol 121:1435~1441
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