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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 2 - 17 (16page)
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Real-time monitoring of biomarkers has important applications in immediately determining, for example, disease progress or therapeutic effects to clinical decisions in the fields of diagnosis, prognosis and therapy. However, technologies developed in this area require frequent sample drawings, unattended analysis in situ, secure online monitoring, and, above all, patient’s safety, so from this point of view are still in their infancy. Current research activity in the area has been restricted to the extent of monitoring physical signals while glucose is the only biomarker generally monitored in real-time. To realize the future of unattended analysis, our research group has investigated various immuno-analytical concepts that enable, in particular, repetitive measurements of target biomarkers in a continuous or semi-continuous manner. The key actors in these achievements were monoclonal antibodies with unique characteristics, raised in our group, that potentially allow for real- time monitoring of target disease markers from tiny ionic molecules to complex proteins. Furthermore, we have investigated surrogate elements (e.g. receptors and cytokines) that translate cellular response to measurable signals, enabling us to determine the functional properties of analytes. In this review, continuous and semi-continuous monitoring techniques of different markers for acute myocardial infarction are presented.
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참고문헌 (45)
참고문헌 신청
Liu, C. / 2012 / Real-time monitoring biomarker expression of carcinoma cells by surface plasmon resonance biosensors / Chem. Commun 48:10389~10391
Shao, H. / 2012 / Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy / Nat. Med 18:1835~1841
Arroyo-Currás, N. / 2017 / Real-time measurement of small molecules directly in awake, ambulatory animals / Proc. Natl. Acad. Sci. U. S. A 114:645~650
Patel, S. / 2012 / A review of wearable sensors and systems with application in rehabilitation / J. NeuroEng. Rehabil 9:21
Girardin, C. M. / 2009 / Continuous glucose monitoring: A review of biochemical perspectives and clinical use in type 1 diabetes / Clin. Biochem 42:136~142
Shao, H. / 2012 / Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy / Nat. Med 18:1835~1841
Arroyo-Currás, N. / 2017 / Real-time measurement of small molecules directly in awake, ambulatory animals / Proc. Natl. Acad. Sci. U. S. A 114:645~650
Patel, S. / 2012 / A review of wearable sensors and systems with application in rehabilitation / J. NeuroEng. Rehabil 9:21
Girardin, C. M. / 2009 / Continuous glucose monitoring: A review of biochemical perspectives and clinical use in type 1 diabetes / Clin. Biochem 42:136~142
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