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논문 기본 정보

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저자정보
Pierre-Alain Reboux (Department of Gynecological and Breast Surgery and Oncology Pitié-Salpêtrière University Hospital) Henri Azaïs (Department of Gynecological and Breast Surgery and Oncology Pitié-Salpêtrière University Hospital) Charles-Henry Canova (Department of Radiation Oncology Pitié-Salpêtrière University Hospital) Sofiane Bendifallah (Department of Gynaecology and Obstetrics Tenon University Hospital) Lobna Ouldamer (Department of Gynecology Centre Hospitalier Universitaire de Tours Tours France) Emilie Raimond (Department of Obstetrics and Gynaecology Institute Alix de Champagne University Hospital) Delphine Hudry (Center de Lutte Contre le Cancer Georges François Leclerc Dijon France) Charles Coutant (Center de Lutte Contre le Cancer Georges François Leclerc Dijon France) Olivier Graesslin (Department of Obstetrics and Gynaecology Institute Alix de Champagne University Hospital) Cyril Touboul (Department of Obstetrics and Gynaecology Centre Hospitalier Intercommunal Créteil France) Pierre Collinet (Department of Obstetrics and Gynaecology Centre Hospitalier Régional Universitaire Lille France) Alexandre Bricou (Department of Gynaecology and Obstetrics Jean Verdier University Hospital) Cyrille Huchon (Obstetrics and Gynecology Department Poissy Medical Center Poissy France) Emile Daraï (Department of Gynaecology and Obstetrics Tenon University Hospital) Marcos Ballester (Department of Gynaecology and Obstetrics Tenon University Hospital) Jean Lévêque (CHU de Rennes Service de Gynécologie Hopital Sud Université de Rennes 1 Rennes France) Vincent Lavoué (CHU de Rennes Service de Gynécologie Hopital Sud Université de Rennes 1 Rennes France) Martin Koskas (Division of Gynecologic Oncology Bichat University Hospital Paris France) Catherine Uzan (Department of Gynecological and Breast Surgery and Oncology Pitié-Salpêtrière University Hospital) Geoffroy Canlorbe (Department of Gynecological and Breast Surgery and Oncology Pitié-Salpêtrière University Hospital)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.30 No.4
발행연도
2019.1
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1 - 11 (11page)

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Objective: According to recent European Society of Medical Oncology, European Society of Gynaecological Oncology and European Society of Radiotherapy and Oncology guidelines,adjuvant vaginal brachytherapy (VB) is optional in patients with intermediate risk (IR) and high-intermediate risk (HIR) endometrial cancer (EC). The aim of this French retrospective,multicenter study was to assess the impact of VB in these groups on local recurrence rate,local recurrence-free survival (RFS) and overall survival (OS). Methods: Data of 191 patients with IR and HIR EC who underwent primary surgery with or without VB and no other adjuvant treatment between 2000 and 2016 were extracted from the FRANCOGYN database. Rate of local recurrence, OS and local RFS in these two groups were compared using the Kaplan-Meier method. Results: The number of patients with IR and HIR EC were 118 and 73 respectively. VB was used in 92 patients in IR group and 43 in HIR group. Median follow-up was 22 months. In the HIR group, the local recurrence rate was significantly higher in the no adjuvant therapy group in comparison with the VB group (16.7% and 0% respectively, p=0.02). There was also a significant improvement in local RFS (p=0.01) in VB group. In IR EC, there is no significant difference on local recurrence rate (4.2% and 3.2%, respectively, p=1.00) or local RFS (p=0.54) between the two groups. Conclusions: VB is an efficient adjuvant treatment for patients with HIR EC. VB is not associated with an improvement of RFS or OS in IR EC patient.
#Endometrial Cancer #Brachytherapy #Local Neoplasm Recurrence

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참고문헌 (33)

참고문헌 신청
International Agency for Research on Cancers / GLOBOCAN 2012: country fast stat / IARC google schola Baekelandt MM / 2009 / Endometrial carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up / Ann Oncol 20(Suppl 4):29~31 google schola Albertini AF / 2012 / Pathology of endometrioid carcinoma / Bull Cancer 99:7~12 google schola Colombo N / 2016 / ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up / Int J Gynecol Cancer 26:26~22 google schola Sorbe B / 2009 / Intravaginal brachytherapy in FIGO stage I low-risk endometrial cancer : a controlled randomized study / Int J Gynecol Cancer 19:873~878 google schola

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