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논문 기본 정보

자료유형
학술저널
저자정보
Byeong Geun Song (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Yang Won Min (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Hyuk Lee (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Byung-Hoon Min (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Jun Haeng Lee (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Poong-Lyul Rhee (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Jae J Kim (Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.1
발행연도
2019.1
수록면
75 - 81 (7page)

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Background/Aims Esophagogastric junction outflow obstruction (EGJOO) is a diagnostically heterogeneous group with variable clinical relevance. We studied whether evaluation of bolus transit by multichannel intraluminal impedance (MII) is useful for discriminating clinically relevant EGJOO. Methods A total 169 patients diagnosed as having EGJOO between June 2011 and February 2018 were analyzed. All the patients received a combined MII and high-resolution manometry (CMII-HRM). MII was reported as having abnormal liquid bolus transit (LBT) if < 80% of swallows had complete bolus transit. EGJOO was defined as a median integrated relaxation pressure of > 20 mmHg and when the criteria for achalasia were not met. Patients who progress to achalasia, show significant passage disturbance, or require pneumatic dilatation were defined as having a clinically relevant EGJOO. Results Among the patients with EGJOO (n = 169), the clinically relevant group (n = 10) is more likely to have dysphagia (100% vs 25.2%, P < 0.001), compartmentalized pressurization (CP; 90.0% vs 22.0%, P < 0.001), and abnormal LBT (100% vs 66.7%, P = 0.032) compared to the non-relevant group (n = 159). The combination of dysphagia, CP, and abnormal LBT showed the best predictive power for clinically relevant EGJOO (sensitivity 90%, specificity 92.5%, positive predictive value 42.9%, negative predictive value 99.3%, positive likelihood ratio 11.9, and negative likelihood ratio 0.1). When CMII-HRM was used, an additional 8.3% of clinically relevant EGJOO cases were identified as compared with HRM alone. Conclusion Clinically relevant EGJOO can be predicted using CMII-HRM.

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