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논문 기본 정보

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학술저널
저자정보
Valeria Schindler (Division of Gastroenterology and Hepatology University Hospital Zurich Switzerland) Daniel Runggaldier (Division of Gastroenterology and Hepatology University Hospital Zurich Switzerland) Amanda Bianca (Division of Gastroenterology and Hepatology University Hospital Zurich Switzerland) Anton S Becker (Institute of Diagnostic and Interventional Radiology University Hospital Zurich Switzerland) Fritz Murray (Division of Gastroenterology and Hepatology University Hospital Zurich Switzerland) Edoardo Savarino (Department of Surgery Oncology and Gastroenterology University of Padua Italy) Daniel Pohl (Division of Gastroenterology and Hepatology University Hospital Zurich Switzerland)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.2
발행연도
2019.1
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205 - 211 (7page)

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Background/Aims The influence of external factors such as opioids and alcohol has been extensively investigated for various segments of the gastrointestinal tract. However, the association between their use and the development of esophagogastric junction outflow obstruction disorders (EGJOODs) is unknown. Therefore, the aim of this study is to analyze prevalence and clinical relevance of opioids and alcohol intake in patients with EGJOODs. Methods In this single-center, retrospective study, we reviewed clinical and pharmacological data of 375 consecutive patients who had undergone high resolution impedance manometry for EGJOODs. EGJOODs were classified according to the Chicago classification version 3.0 and to recently published normal values for test meals. Demographics, manometric data, and symptoms were compared between different groups using Pearson’s chi-squared test, Fisher’s exact test, and multivariate analysis. A P < 0.05 was considered significant. Results EGJOOD was found in 30.7% (115/375) of all analyzed patients. The prevalence of opioids (14.8% vs 4.2%, P = 0.026) was significantly higher in patients with EGJOODs compared to patients without EGJOODs. Additionally, excessive alcohol consumption (12.2% vs 3.5%, P = 0.011) was associated with EGJOODs. Excessive alcohol consumption was especially frequent in the non-achalasia esophagogastric junction outflow obstruction subgroup (16.2%) and opioid use in the achalasia type III subgroup (20.0%). Conclusions We found a significant association between EGJOODs and opioid as well as excessive alcohol consumption. This underlines the importance of detailed history taking regarding medication and ethanol consumption in patients with dysphagia. Further prospective studies on mechanisms undelaying esophagogastric junction dysfunction due to opioids or alcohol are warranted.
#Alcohol drinking #Analgesics #Opioids #Esophageal achalasia #Esophagogastric junction #Manometry

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참고문헌 (30)

참고문헌 신청
Tuason J / 2017 / Current status of achalasia management : a review on diagnosis and treatment / J Gastroenterol 52:401~406 google schola Kahrilas PJ / 2015 / The Chicago classification of esophageal motility disorders, v3.0 / Neurogastroenterol Motil 27:160~174 google schola Hollenstein M / 2017 / Pharyngeal swallowing and oesophageal motility during a solid meal test : a prospective study in healthy volunteers and patients with major motility disorders / Lancet Gastroenterol Hepatol 2:644~653 google schola Furuzawa-Carballeda J / 2016 / New insights into the pathophysiology of achalasia and implications for future treatment / World J Gastroenterol 22:7892~7907 google schola Park W / 2005 / Etiology and pathogenesis of achalasia : the current understanding / Am J Gastroenterol 100:1404~1414 google schola

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