지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 54 - 61 (8page)
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Background: Several factors had been suggested to contribute to the development of hypertension in chronic glomerulonephritis (GN). This study was conducted to find the association of baseline blood pressure (BP) with pathophysiologic findings and later renal progression in chronic GN. Methods: Clinico-pathological findings including serum creatinine (Cr), proteinuria, pathological findings, and urinary Na excretion were analyzed in a total of 233 patients with IgA nephropathy from The Kyung-Hee Cohort of GN. Glomerular surface area (GSA) was measured by imaging analysis and urine angiotensinogen (AGT) concentrations by human ELISA kits. Results: Systolic BP was ≥130mmHg in 124 patients (53%). Systolic BP was negatively correlated with follow-up eGFR (r=-0.32, p<0.0001) and positively serum uric acid concentrations, while it had no significant relationships with initial serum Cr and eGFR. As compared with patients with systolic BP <130 mmHg, those with ≥130 mmHg were older and showed higher serum Cr, proteinuria, 24 hr urinary Na excretion, mean GSA, and T-I fibrosis, lower follow-up eGFR, and steeper decline in slope of eGFR. The results in patients with normal serum Cr concentrations were comparable to those in whole group. Systolic BP was positively correlated with age, baseline and follow-up proteinuria, serum uric acid concentrations and IgM deposit and negatively with follow-up eGFR. In subgroup analysis, systolic BP was also positively correlated with mean GSA and urinary AGT concentrations. Conclusion: This study showed that baseline systolic BP is related to urinary Na excretion, glomerulomegaly, T-I fibrosis and later renal progression in patients with IgA nephropathy.
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참고문헌 (24)
참고문헌 신청
Orofino L / 1987 / Hypertension in primary chronic glomerulonephritis: analysis of 288 biopsied patients / Nephron 45:22~26
Glassock RJ AS / 1991 / The kidney / The kidney
Berthoux F / 2011 / Predicting the risk for dialysis or death in IgA nephropathy / J Am Soc Nephrol 22:752~761
Csiky B / 1999 / Ambulatory blood pressure monitoring and progression in patients with IgA nephropathy / Nephrol Dial Transplant 14:86~90
Reich HN / 2007 / Toronto Glomerulonephritis R: Remission of proteinuria improves prognosis in IgA nephropathy / J Am Soc Nephrol 18:3177~3183
Glassock RJ AS / 1991 / The kidney / The kidney
Berthoux F / 2011 / Predicting the risk for dialysis or death in IgA nephropathy / J Am Soc Nephrol 22:752~761
Csiky B / 1999 / Ambulatory blood pressure monitoring and progression in patients with IgA nephropathy / Nephrol Dial Transplant 14:86~90
Reich HN / 2007 / Toronto Glomerulonephritis R: Remission of proteinuria improves prognosis in IgA nephropathy / J Am Soc Nephrol 18:3177~3183
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