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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Drug-induced immune hemolytic anemia is a rare disease that occurs in 1 in 1 million individuals of the general population. Rifampin-induced immune hemolytic anemia is caused by drug-dependent antibodies and this can be treated without complication by drug cessation. Herein, we present a case of rifampin-induced immune hemolytic anemia in a patient with primary Sjogren’s syndrome (pSS) which occurred during treatment of pulmonary tuberculosis. At admission, the patient’s laboratory tests revealed hemolytic anemia and positive direct antiglobulin test result. Since the incidence of autoimmune hemolytic anemia (AIHA) in pSS is reported to be 3 percent, which is higher than that of the general population, differential diagnosis between AIHA and rifampin-induced immune hemolytic anemia was required for planning future anti-tuberculous treatment. We identified rifampin-dependent antibody by drug-induced immune complex test and diagnosed rifampin-induced immune hemolytic anemia. Based on this experience, if rifampin administration is considered in patients with systemic autoimmune disease such as pSS, which has a high incidence of AIHA, we suggest evaluating the presence and the cause of hemolytic anemia at baseline by testing serum lactate dehydrogenase, haptoglobin, and direct and indirect antiglobulin tests before drug administration to promptly identify the cause of hemolysis if hemolytic anemia develops. (Korean J Blood Transfus 2019;30:246-252)
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참고문헌 (15)
참고문헌 신청
Garratty G / 2009 / Drug-induced immune hemolytic anemia / Hematology Am Soc Hematol Educ Program :73~79
Garratty G / 2014 / Drugs that have been shown to cause drug-induced immune hemolytic anemia or positive direct antiglobulin tests: some interesting findings since 2007 / Immunohematology 30:66~79
Zhou JG / 2010 / Clinical analysis of primary Sjögren’s syndrome complicating anemia / Clin Rheumatol 29:525~529
Wen W / 2015 / Clinical and serologic features of primary Sjögren’s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study / Clin Rheumatol 34:1877~1884
Han KS / 2014 / Transfusion medicine / Korea Medical Book Publisher :407~408
Garratty G / 2014 / Drugs that have been shown to cause drug-induced immune hemolytic anemia or positive direct antiglobulin tests: some interesting findings since 2007 / Immunohematology 30:66~79
Zhou JG / 2010 / Clinical analysis of primary Sjögren’s syndrome complicating anemia / Clin Rheumatol 29:525~529
Wen W / 2015 / Clinical and serologic features of primary Sjögren’s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study / Clin Rheumatol 34:1877~1884
Han KS / 2014 / Transfusion medicine / Korea Medical Book Publisher :407~408
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