지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한응급의학회 Clinical and Experimental Emergency Medicine Clinical and Experimental Emergency Medicine Vol.6 No.2
- 발행연도
- 2019.1
- 수록면
- 160 - 168 (9page)
이용수
초록· 키워드
오류제보하기
Objective Patients suspected as having acute ischemic stroke usually undergo blood tests, including coagulation-related indexes, because thrombocytopenia and coagulopathy are contraindications for recombinant tissue plasminogen activator (rtPA) administration. We aimed to identify blood test indexes associated with symptomatic intracranial hemorrhage (sICH) in patients with acute ischemic stroke who received intravenous rtPA.Methods This retrospective observational study included patients diagnosed with acute ischemic stroke who were treated with intravenous rtPA at the emergency department of a tertiary hospital in Seoul between February 2008 and January 2018. Blood test indexes were compared between the sICH and non-sICH groups. Logistic regression and receiver-operating characteristic curve analyses were performed.Results In this study, 375 patients were finally included. Of 375 patients, 42 (11.2%) showed new intracranial hemorrhage on follow-up brain computed tomography, of whom 14 (3.73%) had sICH. Platelet count, aspartate aminotransferase and lactate dehydrogenase levels were significantly different between the sICH and non-sICH groups, and platelet count showed statistical significance in the regression analysis. Significantly lower platelet counts were observed in the sICH group than in the non-sICH group (174,500 vs. 228,000/mm3, P=0.020). The best cutoff platelet count was 195,000/mm3, and patients with platelet counts of <195,000/mm3 had a 5.4- times higher risk of developing sICH than those with platelet counts of ≥195,000/mm3.Conclusion Platelet count was the only independent parameter associated with sICH among the blood test indexes. Mild thrombocytopenia may increase the risk of sICH after intravenous administration of rtPA.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Powers WJ / 2015 / 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 46:3020~3035
National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group / 1995 / Tissue plasminogen activator for acute ischemic stroke / N Engl J Med 333:1581~1587
Hacke W / 1998 / Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators / Lancet 352:1245~1251
Wahlgren N / 2007 / Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study / Lancet 369:275~282
Hacke W / 2008 / Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke / N Engl J Med 359:1317~1329
National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group / 1995 / Tissue plasminogen activator for acute ischemic stroke / N Engl J Med 333:1581~1587
Hacke W / 1998 / Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators / Lancet 352:1245~1251
Wahlgren N / 2007 / Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study / Lancet 369:275~282
Hacke W / 2008 / Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke / N Engl J Med 359:1317~1329
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio in Chronic Urticaria
Annals of Dermatology
2019 .01
-
Effectiveness of Platelet Function Analyzer-100 for Laboratory Detection of Anti-Platelet Drug-Induced Platelet Dysfunction
Annals of Laboratory Medicine
2019 .01
-
Platelet count recovery after intravenous immunoglobulin predicts a favorable outcome in children with immune thrombocytopenia
Blood Research
2016 .01
-
Pre-treatment Elevated Platelet Count Associates with HER2 Overexpression and Prognosis in Patients with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Evaluation of Platelet Indices in Lung Cancer Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Liver transplantation of a patient with extreme thrombocytopenia - A case report -
Anesthesia and Pain Medicine
2021 .01
-
Prognostic Impact of Increased Perioperative Platelet Count in Gastric Cancer Patients
대한외과학회 학술대회 초록집
2019 .05
-
Thapsigargin Induces Platelet Aggregation, thereby Releases Lactate Dehydrogenase from Rat Platelets
대한의생명과학회지
2021 .09
-
Effects and treatment applications of polymeric nanoparticles on improving platelets’ storage time: a review of the literature from 2010 to 2020
Blood Research
2021 .12
-
An Elevated Platelet Count Increases the Risk of Relapse in Ulcerative Colitis Patients with Mucosal Healing
Gut and Liver
2018 .01
-
The incidence of postoperative hemorrhage after tooth extraction in patients with thrombocytopenia
대한구강악안면외과학회지
2021 .06
-
Replication Study of Genome-Wide Association Study of Platelet Count in Korean Health Examinees (HEXA) Cohort
대한의생명과학회지
2021 .09
-
Characterization of the distinct mechanism of agonist-induced canine platelet activation
Journal of Veterinary Science
2019 .01
-
Expanded Impacts of Platelet Functions: Beyond Hemostasis and Thrombosis
Annals of Laboratory Medicine
2019 .01
-
Platelet count as an important prognostic factor for vaccine-induced immune thrombotic thrombocytopenia
Blood Research
2021 .09
-
Platelet Serotonin Concentration Is Associated with Illness Duration in Schizophrenia and Chronological Age in Depression
PSYCHIATRY INVESTIGATION
2020 .01
-
Tobacco Use: A Major Risk Factor of Intracerebral Hemorrhage
대한뇌졸중학회지
2021 .01
-
클로피도그렐 또는 티카그렐러로 치료받는 환자에서 혈소판 수와 특성이 혈소판 반응성에 미치는 영향
대한내과학회지
2017 .01
-
Efficacy and safety of eltrombopag in adult refractory immune thrombocytopenia
Blood Research
2015 .01
-
Is there an association between platelet and blood inflammatory indices and the risk of gestational diabetes mellitus?
Obstetrics & Gynecology Science
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0