지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한응급의학회 Clinical and Experimental Emergency Medicine Clinical and Experimental Emergency Medicine Vol.6 No.1
- 발행연도
- 2019.1
- 수록면
- 84 - 88 (5page)
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초록· 키워드
오류제보하기
Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from cocaine or bupropion use. We report acute toxicity from the concomitant use of cocaine and bupropion in a 25-year-old female. She arrived agitated and uncooperative, with a history of possible antecedent cocaine use. Her electrocardiogram demonstrated tachycardia at 130 beats/min, with a corrected QT interval of 579 ms. Two doses of 5 mg intravenous metoprolol were administered, which resolved the agitation, tachydysrhythmia, and corrected QT interval prolongation. Her comprehensive toxicology screen returned positive for both cocaine and bupropion. We believe clinicians should be aware of the potential for synergistic cardiovascular and CNS toxicity from concomitant cocaine and bupropion use. Metoprolol may represent an effective initial treatment. Unlike benzodiazepines, metoprolol directly counters the pharmacologic effects of stimulants without respiratory depression, sedation, or paradoxical agitation. A lipophilic beta-blocker, metoprolol has good penetration of the CNS and can counter stimulant-induced agitation.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Richards JR / 2016 / Treatment of cocaine cardiovascular toxicity: a systematic review / Clin Toxicol (Phila) 54:345~364
Richards JR / 2017 / β-blockers, cocaine, and the unopposed α-stimulation phenomenon / J Cardiovasc Pharmacol Ther 22:239~249
Foley KF / 2006 / Bupropion: pharmacology and therapeutic applications / Expert Rev Neurother 6:1249~1265
Ritz MC / 1997 / Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality / Psychopharmacology (Berl) 129:311~321
Pederson KJ / 2001 / Acute myocardial ischemia associated with ingestion of bupropion and pseudoephedrine in a 21-year-old man / Can J Cardiol 17:599~601
Richards JR / 2017 / β-blockers, cocaine, and the unopposed α-stimulation phenomenon / J Cardiovasc Pharmacol Ther 22:239~249
Foley KF / 2006 / Bupropion: pharmacology and therapeutic applications / Expert Rev Neurother 6:1249~1265
Ritz MC / 1997 / Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality / Psychopharmacology (Berl) 129:311~321
Pederson KJ / 2001 / Acute myocardial ischemia associated with ingestion of bupropion and pseudoephedrine in a 21-year-old man / Can J Cardiol 17:599~601
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