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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 196 - 196 (1page)
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Cocaine is a worldwide used drug, but its abuse is associated with physical, psychiatric and social problems. Cocaine abuse has been known to cause liver toxicity, but the mechanism remains unknown. Mitochondrial dysfunction and reactive oxygen species (mtROS) have been suggested to be critical for the progression of drug-induced liver injury and inflammation. Mitochondrial membrane potential(ΔΨm) plays a key role in mitochondrial homeostasis. And loss of mitochondrial membrane potential may reduce cell viability and cause various pathologies. Thus, we investigated cocaine-induced liver injury and inflammation through regulation of mitochondrial quality control. We found that cocaine increases hepatocytes death in dose-dependent manner. Moreover, coc ... 전체 초록 보기
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