지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 126 - 135 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: This study evaluated the test-retest repeatability and measurement variability of ultrasonographic shear wave elastography (SWE) for liver stiffness in a rat liver fibrosis model. Methods: In 31 Sprague-Dawley rats divided into three groups (high-dose, low-dose, and control), liver fibrosis was induced by intraperitoneal administration of thioacetamide for 8 weeks. A dedicated radiographer performed SWE to measure liver stiffness in kilopascals in two sessions at a 3-day interval. We calculated correlations between liver stiffness and histopathologic results, measurement variability in each session using coefficients of variation (CoVs) and interquartile/median (IQR/M), and test-retest repeatability between both sessions using the repeatability coefficient. Results: Different levels of liver fibrosis in each group were successfully induced in the animal model. The mean liver stiffness values were 8.88±1.48 kPa in the control group, 11.62±1.70 kPa in the low-dose group, and 11.91±1.73 kPa in the high-dose group. The correlation between collagen areas and liver stiffness values was moderate (r=0.6). In all groups, the second session yielded lower CoVs (i.e., more reliable results) for liver stiffness than the first session, suggesting a training effect for the operator. The mean IQR/M values were also lower in the second session than in the first session, which had four outliers (0.21 vs. 0.12, P<0.001). The test-retest repeatability coefficient was 3.75 kPa and decreased to 2.82 kPa after removing the four outliers. Conclusion: The use of ultrasonographic SWE was confirmed to be feasible and repeatable for evaluating liver fibrosis in preclinical trials. Operator training might reduce variability in liver stiffness measurements.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Katsutoshi Sugimoto / 2020 / Clinical utilization of shear wave dispersion imaging in diffuse liver disease / ULTRASONOGRAPHY 39(1):3~10
홍은경 / 2018 / Accurate measurements of liver stiffness using shear wave elastography in children and young adults and the role of the stability index / ULTRASONOGRAPHY 37(3):226~232
정우경 / 2014 / Principles and clinical application of ultrasound elastography for diffuse liver disease / ULTRASONOGRAPHY 33(3):149~160
Chen YW / 2014 / Gadoxetic acid-enhanced MRI and sonoelastography: non-invasive assessments of chemoprevention of liver fibrosis in thioacetamideinduced rats with Sho-Saiko-To / PLoS One 9:e114756
You MW / 2017 / A metaanalysis for the diagnostic performance of transient elastography for clinically significant portal hypertension / Ultrasound Med Biol 43:59~68
홍은경 / 2018 / Accurate measurements of liver stiffness using shear wave elastography in children and young adults and the role of the stability index / ULTRASONOGRAPHY 37(3):226~232
정우경 / 2014 / Principles and clinical application of ultrasound elastography for diffuse liver disease / ULTRASONOGRAPHY 33(3):149~160
Chen YW / 2014 / Gadoxetic acid-enhanced MRI and sonoelastography: non-invasive assessments of chemoprevention of liver fibrosis in thioacetamideinduced rats with Sho-Saiko-To / PLoS One 9:e114756
You MW / 2017 / A metaanalysis for the diagnostic performance of transient elastography for clinically significant portal hypertension / Ultrasound Med Biol 43:59~68
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
비침습적 간섬유화 검사의 적용
대한내과학회지
2023 .04
-
Liver
대한외과학회 학술대회 초록집
2016 .11
-
Intra-individual comparison of twodimensional shear wave elastography techniques using plane wave imaging and the multi-beam technique: are they interchangeable in measuring liver fibrosis?
ULTRASONOGRAPHY
2023 .04
-
Clinical application of liver stiffness measurement for assessing the risk of hepatocellular Carcinoma
Journal of Liver Cancer
2019 .01
-
Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
Gut and Liver
2016 .01
-
Anti-fibrotic treatments for chronic liver diseases: The present and the future
Clinical and Molecular Hepatology
2021 .01
-
Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future
Clinical and Molecular Hepatology
2023 .02
-
간경변의 진단
대한의사협회지
2017 .01
-
Current role of transient elastography in the management of chronic hepatitis B patients
ULTRASONOGRAPHY
2017 .01
-
Noninvasive serum biomarkers for liver fibrosis in NAFLD: current and future
Clinical and Molecular Hepatology
2023 .02
-
A novel autophagy inducer, AS777, ameliorates liver fibrosis via suppressing liver inflammation
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Beyond Liver Disease: Non-Alcoholic Fatty Liver Disease and Advanced Liver Fibrosis in Kidney Disease
Diabetes and Metabolism Journal
2022 .07
-
Updates in the quantitative assessment of liver fibrosis for nonalcoholic fatty liver disease: Histological perspective
Clinical and Molecular Hepatology
2021 .01
-
Non-invasive biomarkers of liver fibrosis in non-alcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .04
-
Identification of high-risk subjects in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
Inter-platform reproducibility of liver stiffness measured with two different point shear wave elastography techniques and 2-dimensional shear wave elastography using the comb-push technique
ULTRASONOGRAPHY
2019 .01
-
Peri-Operative Liver Fibrosis and Native Liver Survival in Pediatric Patients with Biliary Atresia: A Systematic Review and Meta-Analysis
Pediatric Gastroenterology, Hepatology & Nutrition
2022 .09
-
Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
Diabetes and Metabolism Journal
2022 .07
-
초음파 B-모드 영상에서 FCN(fully convolutional network) 모델을 이용한 간 섬유화 단계 분류 알고리즘
의공학회지
2020 .01
-
The factor that improve liver stiffness in patients with chronic hepatitis B
Clinical and Molecular Hepatology
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0