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학술저널
저자정보
Gyu Hur (Inje University Haeundae Paik Hospital) Min Seob Song (Inje University) Sejung Sohn (Ewha Womans University) 이형두 (부산대학교) Gi Beom Kim (Seoul National University Children’s Hospital) Hwa Jin Cho (Chonnam National University) Kyung Lim Yoon (Kyung Hee University Hospital at Gangdong Seoul Korea) Chan Uhng Joo (Chonbuk National University Medical School Children's Hospital) Myung Chul Hyun (Kyungpook National University) Chul-HoKim (Inje University)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.49 No.2
발행연도
2019.1
수록면
183 - 191 (9page)

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Background and Objectives: We investigated the status of infliximab use in intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients and the incidence of coronary artery aneurysms (CAAs) according to treatment regimens. Methods: Between March 2010 and February 2017, 16 hospitals participated in this study. A total of 102 (32.3±19.9 months, 72 males) who received infliximab at any time after first IVIG treatment failure were enrolled. Data were retrospectively collected using a questionnaire. Results: Subjects were divided into two groups according to the timing of infliximab administration. Early treatment (group 1) had shorter fever duration (10.5±4.4 days) until infliximab infusion than that in late treatment (group 2) (16.4±4.5 days; p<0.001). We investigated the response rate to infliximab and the incidence of significant CAA (z-score >5). Overall response rate to infliximab was 89/102 (87.3%) and the incidence of significant CAA was lower in group 1 than in group 2 (1/42 [2.4%] vs. 17/60 [28.3%], p<0.001). Conclusions: This study suggests that the early administration of infliximab may reduce the incidence of significant CAA in patients with IVIG-resistant KD. However, further prospective randomized studies with larger sample sizes are required.

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