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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.30 No.2
- 발행연도
- 2021.1
- 수록면
- 178 - 183 (6page)
이용수
초록· 키워드
오류제보하기
Background: The oral glucose tolerance test (OGTT)-glucose response curves (GRCs; incessant increase, monophasic, and biphasic) reflect insulin sensitivity and β-cell function, being worse in the former and superior in the latter. Here, we examined if the OGTT-GRC pattern is worse in obese antibody (glutamic acid decarboxylase 65-kDa [GAD65] and insulinoma-associated protein-2 [IA-2])-positive (Ab+) vs. –negative (Ab–) youth clinically diagnosed with type 2 diabetes (CDX-T2D). Methods: Forty-seven obese youth, 15 Ab+ and 32 Ab–, were divided into three OGTT-GRC groups: incessant increase, monophasic, and biphasic. The prevalence of OGTT-GRC, clamp-measured insulin sensitivity, and β-cell function was compared. Results: Incessant increase OGTT-GRC is the most frequent curve type and is three-fold higher in Ab+ vs. Ab– youth CDX-T2D. In Ab+ youth, there was up to 40% lower second-phase insulin secretion in the incessant increase group vs. the other two groups combined (monophasic and biphasic). In Ab– youth, while first- and second-phase insulin secretion was significantly lower in the incessant increase vs. the other two groups combined, overall β-cell function was less impaired than in Ab+ youth. In neither Ab– or Ab+ youth was OGTT-GRC related to hepatic or peripheral insulin sensitivity. Conclusion: Severe insulin deficiency, a characteristic of type 1 diabetes, seems to be related to higher prevalence of incessant increase in Ab+ vs. Ab– obese youth.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Kim JY / 2016 / The shape of the glucose response curve during an oral glucose tolerance test heralds biomarkers of type 2 diabetes risk in obese youth / Diabetes Care 39:1431~1439
Arslanian S / 2019 / The shape of the glucose response curve during an oral glucose tolerance test : forerunner of heightened glycemic failure rates and accelerated decline in β-cell function in TODAY / Diabetes Care 42:164~172
Tfayli H / 2009 / Phenotypic type 2diabetes in obese youth : insulin sensitivity and secretion in islet cell antibody-negative versus-positive patients / Diabetes 58:738~744
Tfayli H / 2010 / Islet cell antibodypositive versus -negative phenotypic type 2 diabetes in youth:does the oral glucose tolerance test distinguish between the two? / Diabetes Care 33:632~638
Tanner JM / 1981 / Growth and maturation during adolescence / Nutr Rev 39:43~55
Arslanian S / 2019 / The shape of the glucose response curve during an oral glucose tolerance test : forerunner of heightened glycemic failure rates and accelerated decline in β-cell function in TODAY / Diabetes Care 42:164~172
Tfayli H / 2009 / Phenotypic type 2diabetes in obese youth : insulin sensitivity and secretion in islet cell antibody-negative versus-positive patients / Diabetes 58:738~744
Tfayli H / 2010 / Islet cell antibodypositive versus -negative phenotypic type 2 diabetes in youth:does the oral glucose tolerance test distinguish between the two? / Diabetes Care 33:632~638
Tanner JM / 1981 / Growth and maturation during adolescence / Nutr Rev 39:43~55
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