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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 439 - 451 (13page)
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Background: Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in the regulation of metabolism is not fully understood. MondoA is a glucose-sensing transcription factor that is highly expressed in skeletal muscle. Previous studies suggest that MondoA can influence systemic metabolism homeostasis. However, the function of MondoA in the skeletal muscle remains unclear. Methods: We generated muscle-specific MondoA knockout (MAKO) mice and analyzed the skeletal muscle morphology and glycogen content. Along with skeletal muscle from MAKO mice, C2C12 myocytes transfected with small interfering RNA against MondoA were also used to investigate the role and potential mechanism of MondoA in the development and glycogen metabolism of skeletal muscle. Results: MAKO caused muscle fiber atrophy, reduced the proportion of type II fibers compared to type I fibers, and increased the muscle glycogen level. MondoA knockdown inhibited myoblast proliferation, migration, and differentiation by inhibiting the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway. Further mechanistic experiments revealed that the increased muscle glycogen in MAKO mice was caused by thioredoxin-interacting protein (TXNIP) downregulation, which led to upregulation of glucose transporter 4 (GLUT4), potentially increasing glucose uptake. Conclusion: MondoA appears to mediate mouse myofiber development, and MondoA decreases the muscle glycogen level. The findings indicate the potential function of MondoA in skeletal muscle, linking the glucose-related transcription factor to myogenesis and skeletal myofiber glycogen metabolism.
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참고문헌 (42)
참고문헌 신청
Bassel-Duby R / 2006 / Signaling pathways in skeletal muscle remodeling / Annu Rev Biochem 75:19~37
Schiaffino S / 2010 / Fibre types in skeletal muscle: a personal account / Acta Physiol(Oxf) 199:451~463
Billin AN / 2000 / MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network / Mol Cell Biol 20:8845~8854
Li MV / 2006 / Glucosedependent transcriptional regulation by an evolutionarily conserved glucose-sensing module / Diabetes 55:1179~1189
Yamashita H / 2001 / A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver / Proc Natl Acad Sci U S A 98:9116~9121
Schiaffino S / 2010 / Fibre types in skeletal muscle: a personal account / Acta Physiol(Oxf) 199:451~463
Billin AN / 2000 / MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network / Mol Cell Biol 20:8845~8854
Li MV / 2006 / Glucosedependent transcriptional regulation by an evolutionarily conserved glucose-sensing module / Diabetes 55:1179~1189
Yamashita H / 2001 / A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver / Proc Natl Acad Sci U S A 98:9116~9121
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