지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 186 - 192 (7page)
이용수
초록· 키워드
오류제보하기
Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect of evogliptin, a DPP-4 inhibitor, has not been studied. Here, we report the beneficial effects of evogliptin on unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice. Evogliptin attenuated UUO-induced renal atrophy and tubulointerstitial fibrosis. Immunohistochemistry and Western blotting demonstrated that evogliptin treatment inhibits pro-fibrotic gene expressions and extracellular matrix production. In vitro findings showed that the beneficial effects of evogliptin on renal fibrosis are mediated by inhibition of the transforming growth factor-β/Smad3 signaling pathway. The present study demonstrates that evogliptin is protective against UUO-induced renal fibrosis, suggesting that its clinical applications could extend to the treatment of kidney disease of non-diabetic origin.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Atkins RC / 2010 / Diabetes : diabetic kidney disease : act now or pay later / Nat Rev Nephrol 6:134~136
Meng XM / 2016 / TGF-β : the master regulator of fibrosis / Nat Rev Nephrol 12:325~338
Lan HY / 2012 / TGF-β/Smad signaling in kidney disease / Semin Nephrol 32:236~243
Salvo F / 2016 / Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia : systematic review and meta-analysis / BMJ 353:i2231
Hirakawa H / 2015 / A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice / PLoS One 10:e0119360
Meng XM / 2016 / TGF-β : the master regulator of fibrosis / Nat Rev Nephrol 12:325~338
Lan HY / 2012 / TGF-β/Smad signaling in kidney disease / Semin Nephrol 32:236~243
Salvo F / 2016 / Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia : systematic review and meta-analysis / BMJ 353:i2231
Hirakawa H / 2015 / A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice / PLoS One 10:e0119360
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction
Kidney Research and Clinical Practice
2024 .09
-
Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
Endocrinology and Metabolism
2017 .01
-
Financial Benefits of Renal Dose-Adjusted Dipeptidyl Peptidase-4 Inhibitors for Patients with Type 2 Diabetes and Chronic Kidney Disease
Endocrinology and Metabolism
2024 .08
-
Gemigliptin Attenuates Renal Fibrosis Through Down- Regulation of the NLRP3 Inflammasome
Diabetes and Metabolism Journal
2019 .01
-
An update on renal fibrosis: from mechanisms to therapeutic strategies with a focus on extracellular vesicles
Kidney Research and Clinical Practice
2023 .03
-
Diminazene aceturate exacerbates renal fibrosis after unilateral ureteral obstruction in female mice
Kidney Research and Clinical Practice
2023 .03
-
The flavonoid fisetin ameliorates renal fibrosis by inhibiting SMAD3 phosphorylation, oxidative damage, and inflammation in ureteral obstructed kidney in mice
Kidney Research and Clinical Practice
2023 .05
-
New Era for Renal-Protective Therapy in Type 2 Diabetes: Better Renal Outcomes in Patients with Type 2 Diabetes Taking Sodium-Glucose Cotransporter 2 Inhibitors versus Dipeptidyl Peptidase-4 Inhibitors
Endocrinology and Metabolism
2021 .01
-
Interleukin-10 protects ureteral obstruction-induced renal fibrosis by attenuating oxidative stress and apoptosis
대한체질인류학회 학술대회 연제 초록
2019 .05
-
Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors
Diabetes and Metabolism Journal
2022 .01
-
Fibroblast Growth Factor 21 Attenuates Diabetes- Induced Renal Fibrosis by Negatively Regulating TGF- β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
Diabetes and Metabolism Journal
2020 .01
-
Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients
Diabetes and Metabolism Journal
2015 .01
-
Cell-based therapy for kidney disease
Investigative and Clinical Urology
2015 .01
-
Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients (Diabetes Metab J 2015;39:74-81)
Diabetes and Metabolism Journal
2015 .01
-
Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients (Diabetes Metab J 2015;39:74-81)
Diabetes and Metabolism Journal
2015 .01
-
Alantolactone Attenuates Renal Fibrosis via Inhibition of Transforming Growth Factor β/Smad3 Signaling Pathway
Diabetes and Metabolism Journal
2024 .01
-
Effects of Dipeptidyl Peptidase-4 Inhibitors on Renal Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Endocrinology and Metabolism
2019 .01
-
Protective effects of KRG against renal injury in aged mice
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis
Kidney Research and Clinical Practice
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0