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Danshen Extracts Prevents Obesity and Activates Mitochondrial Function in Brown Adipose Tissue
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논문 기본 정보

Type
Academic journal
Author
조윤희 (연세대학교) EUN JIG LEE (연세대학교) Ku Cheol Ryong (연세대학교) Young-Suk Choi (Yonsei University) Lee Hyeon Jeong (연세대학교)
Journal
Korean Endocrine Society Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.1 KCI Accredited Journals
Published
2021.1
Pages
185 - 195 (11page)

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Danshen Extracts Prevents Obesity and Activates Mitochondrial Function in Brown Adipose Tissue
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Background: Danshen has been widely used in oriental medicine to improve body function. The purpose of this study is to investigate the effect of water-soluble Danshen extract (DE) on weight loss and on activation proteins involved in mitochondrial biogenesis in brown adipose tissue (BAT) in obese mice. Methods: BAT was isolated from 7-week-old male Sprague-Dawley rats, and expression of proteins related to mitochondrial biogenesis was confirmed in both brown preadipocytes and mature brown adipocytes treated with DE. For the in vivo study, low-density lipoprotein receptor knock out mice were divided into three groups and treated for 17 weeks with: standard diet; high fat diet (HFD); HFD+DE. Body weight was measured every week, and oral glucose tolerance test was performed after DE treatment in streptozotocin-induced diabetic mice. To observe the changes in markers related to thermogenesis and adipogenesis in the BAT, white adipose tissue (WAT) and liver of experimental animals, tissues were removed and immediately frozen in liquid nitrogen. Results: DE increased the expression of uncoupling protein 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha in brown preadipocytes, and also promoted the brown adipocyte differentiation and mitochondrial function in the mature brown adipocytes. Reactive oxygen species production in brown preadipocytes was increased depending on the concentration of DE. DE activates thermogenesis in BAT and normalizes increased body weight and adipogenesis in the liver due to HFD. Browning of WAT was increased in WAT of DE treatment group. Conclusion: DE protects against obesity and activates mitochondrial function in BAT.
#Pitavastatin #Observational study #Cholesterol #LDL #Safety #Rhabdomyolysis

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Hossain P / 2007 / Obesity and diabetes in the developing world : a growing challenge / N Engl J Med 356:213~215 google schola Lazar MA / 2005 / How obesity causes diabetes : not a tall tale / Science 307:373~375 google schola Cannon B / 2004 / Brown adipose tissue : function and physiological significance / Physiol Rev 84:277~359 google schola Himms-Hagen J / 1990 / Brown adipose tissue thermogenesis : interdisciplinary studies / FASEB J 4:2890~2898 google schola Dulloo AG / 1984 / Energy balance following sympathetic denervation of brown adipose tissue / Can J Physiol Pharmacol 62:235~240 google schola

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