메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
권혜미 (성균관대학교) 박세은 (성균관대학교) 윤지섭 (성균관대학교) 박철영 (성균관대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.2
발행연도
2020.1
수록면
396 - 406 (11page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects,while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels inpatients with benign thyroid nodule (benign group) and papillary thyroid cancer (PTC; PTC group). The associations between theselevels and the clinicopathological features of PTC were evaluated. Methods: We included 157 patients who underwent thyroid surgery (17% of benign and 83% of PTC group). Clinicopathologicalfeatures including size, lymph node metastasis, extrathyroidal extension (ETE), multifocality, American Thyroid Association riskstratification were evaluated. Results: The age was 42.0 years, and 69% were female. Serum adiponectin and progranulin levels were 6.3 µg/mL and 101.5 ng/mLin the benign group and 5.4 µg/mL and 106.1 ng/mL in the PTC group, respectively (P=0.6 and P=0.4, respectively). Serum adiponectin levels showed no significant differences according to clinicopathological features of PTC. The proportions of patients withprimary tumor size >1 cm were 3%, 5%, 8%, and 8% according to serum progranulin level quartiles, respectively (P=0.03). Theproportions of patients with microscopic/gross ETE were 8%/0%, 9%/1%, 11%/1%, and 11%/2% according to serum progranulinlevel quartiles, respectively. Median serum progranulin level was significantly higher in patients with PTC >1 cm than in patientswith papillary thyroid microcarcinoma (P=0.04, 115.3 ng/mL and 104.7 ng/mL, respectively). Conclusion: Serum adiponectin and progranulin levels showed no significant difference between benign and PTC groups. Increasedserum progranulin levels were significantly associated with PTC >1 cm and microscopic and gross ETE.

목차

등록된 정보가 없습니다.

참고문헌 (40)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0