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논문 기본 정보

자료유형
학술저널
저자정보
조세진 (울산대학교 의과대학 서울아산병원 영상의학과) 백정환 (울산대학교 의과대학 서울아산병원 영상의학과) 정새롬 (울산대학교) 최영준 (울산대학교) 이정현 (울산대학교 의과대학)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.2
발행연도
2020.1
수록면
339 - 350 (12page)

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Background: Ultrasound-guided thermal ablations have become one of the main options for treating benign thyroid nodules. To determine efficacy of thermal ablation of benign thyroid nodules, we performed a meta-analysis of studies with long-term follow-up ofmore than 3 years. Methods: Databases were searched for studies published up to August 25, 2019, reporting patients with benign thyroid nodulestreated with thermal ablation and with follow-up data of more than 3 years. Data extraction and quality assessment were performedaccording to PRISMA guidelines. The analysis yielded serial volume reduction rates (VRRs) of ablated nodules for up to 3 years ormore, and adverse effect of ablation during follow-up. Radiofrequency ablation (RFA) and laser ablation (LA) were compared in asubgroup analysis. Results: The pooled VRRs for ablated nodules showed rapid volume reduction before 12 months, a plateau from 12 to 36 months,and more volume reduction appearing after 36 months, demonstrating long-term maintenance of treatment efficacy. Thermal ablation had an acceptable complication rate of 3.8%. Moreover, patients undergoing nodule ablation showed no unexpected delayedcomplications during the follow-up period. In the subgroup analysis, RFA was shown to be superior to LA in terms of the pooledVRR and the number of patients who underwent delayed surgery. Conclusion: Thermal ablations are safe and effective methods for treating benign thyroid nodules, as shown by a long follow-upanalysis of more than 3 years. In addition, RFA showed superior VRRs compared with LA for the treatment of benign thyroid nodules, with less regrowth and less delayed surgery.

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