메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas
Recommendations
Search

논문 기본 정보

Type
Academic journal
Author
Jean Kim (연세대학교) ju hun Oh (연세대학교 의과대학) Heather Harlem (Endocrinology Research Ipsen Bioscience Inc. Cambridge) Michael D. Culler (Endocrinology Research Ipsen Bioscience Inc. Cambridge) Ku Cheol Ryong (연세대학교) EUN JIG LEE (연세대학교)
Journal
Korean Endocrine Society Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.1 KCI Accredited Journals
Published
2020.1
Pages
177 - 187 (11page)

Usage

cover
Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas
Ask AI
Recommendations
Search

Abstract· Keywords

Report Errors
Background: Acromegaly is a rare disease primarily caused by growth hormone (GH)-secreting pituitary adenomas, and its treatment is costly. Moreover, some patients are unresponsive to treatment. Hence, there are increasing efforts to develop new drugs withimproved effectiveness for this disease. BIM23B065 is a novel chimeric molecule that acts on both somatostatin and dopamine receptors. This study aimed to investigate the effects of BIM23B065 compared with those of a somatostatin receptor analog and a dopamine agonist. Methods: The effects of BIM23B065 on the proliferation, GH and insulin-like growth factor-1 (IGF-1) levels, and extracellular signal-regulated kinase (ERK) 1/2 and cyclic AMP response element binding (CREB) phosphorylation of GH3 cells were investigatedwith MTS assay, enzyme-linked immunosorbent assay, and Western blotting, respectively. The dosage and treatment duration ofBIM23B065 were tested in animal models of GH-secreting pituitary adenoma. The effect of BIM23B065 (3 mg/kg/day) on changesin IGF-1 levels before and after treatment was further investigated. Results: In vitro, BIM23B065 treatment decreased GH release in the culture media and downregulated ERK 1/2 and CREB phosphorylation to 22% and 26%, respectively. In vivo, IGF-1 expression decreased to 50 % after 4 weeks of treatment with BIM23B065using an osmotic pump implant. Moreover, magnetic resonance imaging results showed that the tumor size decreased significantlyfollowing treatment with BIM23B065 for 4 weeks. Conclusion: The novel chimeric molecule was effective in decreasing IGF-1 and GH levels and may serve as an effective therapeuticagent for acromegaly.
#Acromegaly #Therapeutics #Growth hormone #Insulin-like growth factor I #Pituitary neoplasms

Contents

No content found

References (20)

Add References
Katznelson L / 2014 / Acromegaly : an endocrine society clinical practice guideline / J Clin Endocrinol Metab 99:3933~3951 google schola Melmed S / 2009 / Guidelines for acromegaly management : an update / J Clin Endocrinol Metab 94:1509~1517 google schola Chalabi M / 2014 / Somatostatin analogs: does pharmacology impact antitumor efficacy? / Trends Endocrinol Metab 25:115~127 google schola Srirajaskanthan R / 2009 / Expression of somatostatin and dopamine 2 receptors in neuroendocrine tumours and the potential role for new biotherapies / Neuroendocrinology 89:308~314 google schola Gatto F / 2011 / The role of somatostatin and dopamine D2 receptors in endocrine tumors / Endocr Relat Cancer 18:R233~51 google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

Combination Therapy of Conventional and Korean Medicine for Multiple Vertebral Compression Fractures Associated with Postpartum Osteoporosis: A Case Report
Lee, Ki-Beom, Yang 외 9명2018
 How to Apply Linguistic Theories to Chinese Language Teaching: Focused on Teaching Chinese Grammar based on Situation Types Theory
Kim, Yoon-jeongKorea Association of Chinese Language Education2009.05

Comments(0)

0

Write first comments.