메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Park Ji-Won (Department of Biomedical Gerontology Graduate School of Hallym University Chuncheon Korea.Departmen) Kim Mo-Jong (Department of Biomedical Gerontology Graduate School of Hallym University Chuncheon Korea.Ilsong In) Kim Sung-Eun (Department of Internal Medicine Hallym University Medical Center Anyang Korea.Institute for Liver a) Kim Hee-Jun (Ilsong Institute of Life Science Hallym University Anyang Korea.) Jeon Yong-Chul (Ilsong Institute of Life Science Hallym University Anyang Korea.) Shin Hae-Young (Ilsong Institute of Life Science Hallym University Anyang Korea.) Park Se Jin (Ilsong Institute of Life Science Hallym University Anyang Korea.) 장명국 (Institute for Liver and Digestive Diseases Hallym University Chuncheon Korea.Department of Internal) Kim Dong-Joon (Institute for Liver and Digestive Diseases Hallym University Chuncheon Korea.Department of Internal) Park Choong-Kee (Department of Internal Medicine Hallym University Medical Center Anyang Korea.Institute for Liver a) Choi Eun-Kyoung (Department of Biomedical Gerontology Graduate School of Hallym University Chuncheon Korea.Ilsong In)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.14
발행연도
2021.1
수록면
1 - 14 (14page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Liver fibrosis is defined as the accumulation of the extracellular matrix and scar formation. The receptor for advanced glycation end products (RAGE) has been demonstrated to participate in fibrogenesis. S100B is a ligand of RAGE and exerts extracellular functions by inducing a series of signal transduction cascades. However, the involvement of S100B and RAGE in cholestasis-induced liver fibrosis remains unclear. In this study, we investigated S100B and RAGE expression during liver fibrosis in mice that underwent common bile duct ligation (BDL). Methods: BDL was performed in 10-week-old male C57BL/6J mice with sham control (n = 26) and BDL (n = 26) groups. Expression levels of S100B, RAGE and fibrotic markers in the livers from both groups at week 1 and 3 after BDL were examined by western blot and quantitative real-time reverse transcription polymerase chain reaction analysis. Liver fibrotic changes were examined by histological and ultrastructural analysis. Results: Histological staining with Sirius Red and the evaluation of the messenger RNA expression of fibrotic markers showed noticeable periportal fibrosis and bile duct proliferation. S100B was mainly present in bile duct epithelial cells, and its expression was upregulated in proportion to the ductular reaction during fibrogenesis by BDL. RAGE expression was also increased, and interestingly, triple immunofluorescence staining and transmission electron microscopy showed that both S100B and RAGE were expressed in proliferating bile duct epithelial cells and activated hepatic stellate cells (HSCs) of the BDL livers. In addition, in rat HSCs (HSC-T6), treatment with recombinant S100B protein significantly increased fibrotic markers in a dose-dependent manner, and RAGE small interfering RNA (siRNA) suppressed S100B-stimulated upregulation of fibrotic markers compared with cells treated with scramble siRNA and S100B. Conclusion: These findings suggest that the increased expression of S100B and RAGE and the interaction between S100B and RAGE may play an important role in ductular reaction and liver fibrosis induced by BDL.
#S100B #Receptor for Advanced Glycation End Products #Liver Fibrosis #Bile Duct Ligation

목차

등록된 정보가 없습니다.

참고문헌 (41)

참고문헌 신청
Tacke F / 2015 / Mechanisms of liver fibrosis resolution / J Hepatol 63(4):1038~1039 google schola Pinzani M / 2015 / Pathophysiology of liver fibrosis / Dig Dis 33(4):492~497 google schola Lemoinne S / 2013 / Origins and functions of liver myofibroblasts / Biochim Biophys Acta 1832(7):948~954 google schola Xia JR / 2008 / Specific siRNA targeting the receptor for advanced glycation end products inhibits experimental hepatic fibrosis in rats / Int J Mol Sci 9(4):638~661 google schola Yan SF / 2009 / Tempering the wrath of RAGE : an emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation / Ann Med 41(6):408~422 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0