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자료유형
학술저널
저자정보
이영화 (서울대학교) 최영준 (The Warren Alpert Medical School of Brown University) 조성일 (서울대학교) 박혜경 (질병관리본부) 방지환 (서울보라매병원 감염내과) 이종구 (서울대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.34 No.10
발행연도
2019.1
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1 - 5 (5page)

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Background: In Korea, the incidence of varicella has increased despite the introduction of a universal one-dose vaccination for children aged 12–15 months in 2005. A previous study demonstrated that the vaccine effectiveness was insufficient to prevent against varicella. We assessed the effect of the varicella vaccination on disease severity. Methods: Epidemiologic investigation of varicella cases in Seoul metropolitan area from 2015 to 2017 were used. Varicella-related symptoms such as rash were determined by the clinical practitioners. Disease severity of patients was assessed by the number of skin lesions and divided into mild (≤ 50) and moderate (51–249) to severe (≥ 250). Unconditional logistic regression analysis was performed and age was controlled. Results: Among a total of 1,008 varicella cases reported, 869 cases were breakthrough cases and 139 were unvaccinated cases. The risk for occurrence of moderate-to-severe disease in the breakthrough group was 0.57 times less than that of the unvaccinated group. Conclusion: These data suggest that national varicella vaccination may have a significant effect on attenuation of disease severity in children.

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