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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.12 No.6
- 발행연도
- 2020.1
- 수록면
- 1,029 - 1,045 (17page)
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Purpose: Allergen exposure induces aberrant T helper (Th) 2 immune responses in patients with allergic asthma, but not in sensitized asymptomatic and nonallergic subjects. Interleukin (IL)-35-induced regulatory T (iTr35) cells are a new subset of regulatory T cells with immunoregulatory properties. These cells can significantly suppress Th2 responses in seasonal allergic rhinitis. However, it remains unknown whether iTr35 cells are involved in the immunoregulation of allergic asthmatic individuals after specific allergen exposure. Methods: The iTr35 cell frequency in peripheral blood mononuclear cells (PBMCs) was measured in patients with allergic asthma as well as in asymptomatic and healthy subjects. The difference in naïve CD4+ T cell conversion to iTr35 cells in vitro during allergen stimulation was also investigated. The effects of iTr35 cells on naïve CD4+ T cell differentiation into Th2 cells, CD4+CD25− T (Teff) cell proliferation and Th2 cytokine production in vitro were assessed. Results: Significantly reduced iTr35 cell frequencies and IL-35 expression levels were found in asthmatic patients with Derp1 allergy compared with asymptomatic and healthy subjects. Moreover, the circulating iTr35 cell proportion and IL-35 expression level in asthmatic patients gradually decreased with disease severity. Patients with allergic asthma had reduced transformation of naïve CD4+ T cells into iTr35 cells and IL-35 production after allergen exposure compared with asymptomatic and healthy subjects. Most importantly, iTr35 cells inhibited allergen-driven differentiation of naïve CD4+ T cells into Th2 cells, Teff cell proliferation and Th2 cytokine production in an IL-35-dependent manner. Conclusions: The results of our study suggest that iTr35 cells may play an important role in preventing Th2 responses to allergens by secreting IL-35 and that iTr35 cells may be a potential new immune regulator of allergic asthma.
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참고문헌 (38)
참고문헌 신청
Hamid Q / 2009 / Immunobiology of asthma / Annu Rev Physiol 71:489~507
Kim HY / 2010 / The many paths to asthma : phenotype shaped by innate and adaptive immunity / Nat Immunol 11:577~584
Kaiko GE / 2011 / New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma / Curr Opin Allergy Clin Immunol 11:39~45
Leόn B / 2017 / T cells in allergic asthma : key players beyond the Th2 pathway / Curr Allergy Asthma Rep 17:43
Imada M / 1995 / Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture : responses of subjects with allergic rhinitis and normal controls / Immunology 85:373~380
Kim HY / 2010 / The many paths to asthma : phenotype shaped by innate and adaptive immunity / Nat Immunol 11:577~584
Kaiko GE / 2011 / New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma / Curr Opin Allergy Clin Immunol 11:39~45
Leόn B / 2017 / T cells in allergic asthma : key players beyond the Th2 pathway / Curr Allergy Asthma Rep 17:43
Imada M / 1995 / Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture : responses of subjects with allergic rhinitis and normal controls / Immunology 85:373~380
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