Whole Exome Sequencing in the Male Breast Cancer with Prolactinoma: A Case Report and Literature Review

Shuai Hao; Miao Huang; Wuguo Tian; Yi Chen; Jianjie Zhao; Donglin Luo

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자료유형: 학술저널

저자정보: Shuai Hao (Department of Breast Thyroid Surgery Daping Hospital Army Medical University Chongqing China.) Miao Huang (Nursing School Chongqing Medical University Chongqing China.) Wuguo Tian (Department of Breast Thyroid Surgery Daping Hospital Army Medical University Chongqing China.) Yi Chen (Department of Breast Thyroid Surgery Daping Hospital Army Medical University Chongqing China.) Jianjie Zhao (Department of Breast Thyroid Surgery Daping Hospital Army Medical University Chongqing China.) Donglin Luo (Department of Breast Thyroid Surgery Daping Hospital Army Medical University Chongqing China.)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.6

발행연도: 2020.1

수록면: 656 - 664 (9page)

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Male breast cancer (MBC) is rare and accounts for approximately 1% of all breast cancer cases worldwide. Previous studies have suggested that several factors significantly increase the risk of MBC. Prolactinoma has the highest incidence rate among patients with functional pituitary tumors. However, whether prolactinoma is involved in the onset and progression of breast cancer remains unclear. To date, there are only five case reports globally on MBC with concurrent prolactinoma. We hereby describe the first case of MBC with prolactinoma in China. We also explored the patient's genetic profile using whole exome sequencing. Our findings may help advance our understanding of the molecular pathogenesis of MBC. Further molecular analyses of such cases are warranted to improve auxiliary molecular diagnostic methods and targeted therapy for MBC.

#Breast neoplasms #male #Prolactinoma #Whole exome sequencing #Pituitary neoplasms

참고문헌 (15)

참고문헌 신청

Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132

Silvestri V / 2016 / Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 / Breast Cancer Res 18:15

Giordano SH / 2018 / Breast cancer in men / N Engl J Med 378:2311~2320

Romijn JA / 2014 / Hyperprolactinemia and prolactinoma / Handb Clin Neurol 124:185~195

Dekkers OM / 2010 / The risk for breast cancer is not evidently increased in women with hyperprolactinemia / Pituitary 13:195~198

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이 논문의 저자 정보

Hao Shuai

소속기관 Department of Breast Thyroid Surgery Daping Hospital Army Medical University Chongqing China.