지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,260 - 1,269 (10page)
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초록· 키워드
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Purpose Survival of metastatic breast cancer (MBC) patient remains unknown and varies greatly from person to person. Thus, we aimed to construct a nomogram to quantify the survival probability of patients with MBC. Materials and Methods We had included 793 MBC patients and calculated trends of case fatality rate by Kaplan- Meier method and joinpoint regression. Six hundred thirty-four patients with MBC between January 2004 and July 2011 and 159 patients with MBC between August 2011 and July 2013 were assigned to training cohort and internal validation cohort, respectively. We constructed the nomogram based on the results of univariable and multivariable Cox regression analyses in the training cohort and validated the nomogram in the validation cohort. Concordance index and calibration curves were used to assess the effectiveness of nomogram. Results Case fatality rate of MBC was increasing (annual percentage change [APC], 21.6; 95% confidence interval [CI], 1.0 to 46.3; p < 0.05) in the first 18 months and then decreased (APC, 4.5; 95% CI, 8.2 to 0.7; p < 0.05). Metastasis-free interval, age, metastasis location, and hormone receptor status were independent prognostic factors and were included in the nomogram, which had a concordance index of 0.69 in the training cohort and 0.67 in the validation cohort. Calibration curves indicated good consistency between the two cohorts at 1 and 3 years. Conclusion In conclusion, the fatality risk of MBC was increasing and reached the summit between 13th and 18th month after the detection of MBC. We have developed and validated a nomogram to predict the 1- and 3-year survival probability in MBC.
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참고문헌 (30)
참고문헌 신청
DeSantis C / 2014 / Breast cancer statistics, 2013 / CA Cancer J Clin 64:52~62
Miao H / 2014 / Predicting survival of de novo metastatic breast cancer in Asian women: systematic review and validation study / PLoS One 9:e93755
Cardoso F / 2017 / 3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) / Ann Oncol 28:16~33
Turner NC / 2017 / Advances in the treatment of advanced oestrogen-receptor-positive breast cancer / Lancet 389:2403~2414
Harbeck N / 2017 / Breast cancer / Lancet 389:1134~1150
Miao H / 2014 / Predicting survival of de novo metastatic breast cancer in Asian women: systematic review and validation study / PLoS One 9:e93755
Cardoso F / 2017 / 3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) / Ann Oncol 28:16~33
Turner NC / 2017 / Advances in the treatment of advanced oestrogen-receptor-positive breast cancer / Lancet 389:2403~2414
Harbeck N / 2017 / Breast cancer / Lancet 389:1134~1150
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