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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 615 - 615 (1page)
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Recently, gene delivery system having targeting function at the specific tissue has been newly designed and tried the application for gene therapy in wide range of cancers. Gambogic acid(GA) is evaluated as a ligand binding with transferrin receptor using HCT116, colon cancer cell line. Targeted gene carrier, GPgWSC(GA-PEG-WSC-bPEI) tested in this study was successfully synthesized using water soluble chitosan (WSC), branched polyethylenimine (bPEI) and PEGylated gambogic acid (GA) as targeting ligand. GPgWSC (GA-PEG-WSC-bPEI) were prepared with 0.5, 1, 2% of GA ratio and complexed with psiRNA-hBCL2, silencing BCL2 mRNA. By results of 1H NMR spectrum, it was checked that GPgWSC was successfully synthesized. From the electrophoresis tests, it was identified that GPgWSC has an excellent binding capability with psiRNA-hBCL2 and exhibited the condensation ability to compact psiRNA-hBCL2 into uniform nanoparticles. And also, GPgWSC was non-toxic in mammalian cells and erythr ... 전체 초록 보기
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