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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 43 - 43 (1page)
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For intratumoral uptake, the movement of nanoparticles(NPs) to tumor sites distant from the blood vessels is impaired by high interstitial fluid pressure (IFP), vessel density, limited interstitial space, dense networks of collagen fibers, and abundant tumor stromal cells (fibroblasts, immune cells, and tumor-associated macrophages). In addition, the tumor microenvironment can also create hypoxic and acidic conditions. To analyze the distribution of NPs and the existence of hypoxic cells in relation to blood vessels within a solid tumor, microscopic observation of tumor sections (＜10 ㎛) is a well-established method. However, this provides far less information about the spatial distribution of NPs and fails to entirely characterize the quantitative relationship among the penetration depth of NPs, hypoxic regions, and blood vessels due to limited ability to observe tumor region. In this work, we use a tissue optical clearing technique to obtain transparent tissues without sectioning and three dimensional tissue reconstruction, subsequently achieving high-resolution information on tumor microenvironment. The aim of this study was to depict the spatial distribution of liposomal nanoparticles (Lip-Rus) in relation to tumor vasculature, hypoxic regions and clonogenic cells in intact transparent tumor tissues. The spatial distribution showed an apparent lack of Lip-Ru penetrati ... 전체 초록 보기
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