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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 11 - 11 (1page)
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Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 ㎚). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native selfassembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumor-specific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient ... 전체 초록 보기
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