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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 439 - 445 (7page)
이용수
초록· 키워드
오류제보하기
Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
Shirley MW / 2018 / he long view: a selective review of 40years of coccidiosis research / Avian Pathol 41:111~112
Taylor MA / 2007 / Veterinary Parasitology / Blackwell Publishing
Haug A / 2008 / Coccidial infections in commercial broilers: Epidemiological aspects and comparison of Eimeria species identification by morphometric and polymerase chain reaction techniques / Avian Pathol 37:161~170
Blake DP / 2017 / Recombinant anticoccidial vaccines-a cup half full? / Infect Genet Evol 55:358~365
Venkatas J / 2019 / A review of Eimeria antigen identification for the development of novel anticoccidial vaccines / Parasitol Res 118:1701~1710
Taylor MA / 2007 / Veterinary Parasitology / Blackwell Publishing
Haug A / 2008 / Coccidial infections in commercial broilers: Epidemiological aspects and comparison of Eimeria species identification by morphometric and polymerase chain reaction techniques / Avian Pathol 37:161~170
Blake DP / 2017 / Recombinant anticoccidial vaccines-a cup half full? / Infect Genet Evol 55:358~365
Venkatas J / 2019 / A review of Eimeria antigen identification for the development of novel anticoccidial vaccines / Parasitol Res 118:1701~1710
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UCI(KEPA) : I410-ECN-0101-2021-513-002138672