지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 8 - 15 (8page)
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초록· 키워드
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Purpose: Overactive bladder (OAB) is characterized by a series of highly prevalent symptoms among older adults. This study used the Overactive Bladder Symptom Score (OABSS) and Patient Perception of Bladder Condition (PPBC) tools to evaluate the efficacy and stability of solifenacin fumarate in the treatment of OAB.Materials and Methods: This was a prospective, multicenter, single-arm, 12-week study that enrolled 163 OAB patients. The patients received 5 mg/day of solifenacin fumarate. The changes in the OABSS, symptoms, and PPBC scores were evaluated at 0, 4, and 12 weeks. Subgroup analysis of the OABSS and PPBC scores based on sex, diabetes mellitus (DM) status, and body mass index (BMI) were also evaluated.Results: At the baseline (week 0), the mean OABSS for all patients was 8.45±2.38(p=0.199). Subsequently, the mean OABSS declined to 5.41±2.69 (p=0.255) at four weeks and 4.21±2.61 (p=0.240) at 12 weeks. The OABSS subscore and PPBC score decreased significantly during the study (p＜0.01). After cases were stratified according to sex, DM status, and BMI, the mean OABSS (mean and subscore) and PPBC score at four and 12 weeks were also improved significantly relative to the baseline scores (both p＜0.05). The overall incidence of adverse events was 7.36% (12 cases), and three patients (1.82%) permanently discontinued solifenacin fumarate because of the adverse events.Conclusions: Solifenacin fumarate is a safe and effective treatment alternative for relieving OAB symptoms, considering the balance between the efficacy, patients?well-being, and tolerability.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Austin PF / 2016 / The standardization of terminology of lower urinary tract function in children and adolescents : update report from the standardization committee of the International Children's Continence Society / Neurourol Urodyn 35:471~481
Milsom I / 2001 / How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study / BJU Int 87:760~766
Lee YS / 2011 / Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms : results of Korean EPIC study / World J Urol 29:185~190
Irwin DE / 2006 / Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries : results of the EPIC study / Eur Urol 50:1306~1314
Melotti IGR / 2018 / Severe depression and anxiety in women with overactive bladder / Neurourol Urodyn 37:223~228
Milsom I / 2001 / How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study / BJU Int 87:760~766
Lee YS / 2011 / Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms : results of Korean EPIC study / World J Urol 29:185~190
Irwin DE / 2006 / Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries : results of the EPIC study / Eur Urol 50:1306~1314
Melotti IGR / 2018 / Severe depression and anxiety in women with overactive bladder / Neurourol Urodyn 37:223~228
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Overactive Bladder Successfully Treated with Duloxetine in a Female Adolescent
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